PMID: 237092Jun 1, 1975Paper

The gas chromatographic determination of atenolol in biological samples

The Journal of Pharmacy and Pharmacology
B Scales, P B Copsey


Methods are described for the gas chromatographic determination of the B-adrenoceptor blocking agent atenolol (ICI 66,082 Tenormin) in whole blood, serum, tissue and urine. The method involves the extraction of the free base from the prepared biological sample into an organic solvent mixture. Further purification is done by backextracting the base into dilute acid from which, after basification it is extracted again into organic solvent. Any atenolol in the residue remaining after solvent evaporation is converted into a heptafluorobutyrate derivative ready for gas chromatography. Use of an electron-capture detector enables concentrations as low as 0.01 mug ml-minus 1 body fluid and 0.04 mug ml-minus 1 tissue to be measured.


May 1, 1980·European Journal of Clinical Pharmacology·E RivaJ McAinsh
Nov 1, 1979·European Journal of Clinical Pharmacology·A MelanderE Wåhlin-Boll
Jan 1, 1985·European Journal of Clinical Pharmacology·M R WilkinsS J Laugher
May 17, 1978·European Journal of Clinical Pharmacology·J D FitzgeraldJ McAinsh
Nov 14, 1977·European Journal of Clinical Pharmacology·J SassardP Zech
Jan 1, 1982·European Journal of Drug Metabolism and Pharmacokinetics·W Kirch, K G Görg
Jan 1, 1987·Journal of Pharmaceutical and Biomedical Analysis·M A IorioA Doldo
Apr 11, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·F C ChiuK Raymond
Jun 1, 1996·Journal of Pharmaceutical and Biomedical Analysis·F C ChengL C Chang
May 22, 1982·British Medical Journal·A K ScottH G Lovell
Dec 1, 1984·British Medical Journal·R FäldtJ Aursnes
Sep 1, 1977·Journal of Biomedical Materials Research·A CappozzoS Cortesi
Sep 1, 1984·British Journal of Clinical Pharmacology·A K SalahudeenD N Bateman
Sep 1, 1984·British Journal of Clinical Pharmacology·M J KendallS Rolf Smith
Dec 1, 1984·British Journal of Clinical Pharmacology·J WebsterG Hawksworth
May 1, 1980·British Journal of Clinical Pharmacology·M VelascoO Hernández-Pieretti
Mar 1, 1988·British Journal of Clinical Pharmacology·M ScottT J Fitzsimons
Jun 1, 1981·British Journal of Clinical Pharmacology·G Neil-DwyerJ M Cruickshank
Jan 1, 1984·British Journal of Clinical Pharmacology·M E EllisT J Fitzsimons
Oct 1, 1980·Biopharmaceutics & Drug Disposition·J McAinshS H Ellis
Apr 1, 1981·Biopharmaceutics & Drug Disposition·J McAinshJ D Harry
May 1, 1986·Biopharmaceutics & Drug Disposition·J McAinshJ Young
Jul 1, 1983·Biopharmaceutics & Drug Disposition·J McAinsh, B F Holmes
Aug 1, 1981·Circulation·M M Ibrahim, R Mossallam
Nov 16, 1978·European Journal of Clinical Pharmacology·A MelanderN O Sjöberg
Nov 1, 1981·British Journal of Clinical Pharmacology·K J ThorleyJ M Cruickshank
Aug 1, 1981·British Journal of Clinical Pharmacology·J WebsterJ C Petrie
Jan 1, 1982·British Journal of Clinical Pharmacology·J ErikssenS Nitter-Hauge
May 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P R ReevesM J Winrow
Apr 1, 1986·The Journal of Pharmacy and Pharmacology·M K Davies, J McAinsh
Jan 1, 1984·British Journal of Clinical Pharmacology·G HawksworthA Parsons
Apr 1, 1982·British Journal of Clinical Pharmacology·B HallengrenA Melander

Related Concepts

Adrenergic beta-Antagonists
Chromatography, Gas-Liquid

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.