The GAS5 (growth arrest-specific transcript 5) gene fuses to BCL6 as a result of t(1;3)(q25;q27) in a patient with B-cell lymphoma

Cancer Genetics and Cytogenetics
Yuichi NakamuraMasami Bessho

Abstract

The BCL6 gene is frequently disrupted at its 5' noncoding region by 3q27 chromosomal translocations in B-cell lymphoma. As a result of translocation, BCL6 is juxtaposed to reciprocal partners, such as the immunoglobulin (Ig) gene family. Besides the Ig loci, multiple non-Ig partners of the BCL6 translocation have been reported. Here we describe the identification of the GAS5 (growth arrest-specific transcript 5) gene as a novel partner of the BCL6 in a patient with diffuse large B-cell lymphoma, harboring the t(1;3)(q25;q27). In this case, the chromosome 1 breakpoint was located within the intronic small nucleolar RNA (snoRNA) sequence of GAS5 and the chromosome 3 breakpoint at 4 kb upstream of BCL6 exon 1a. As the result of chromosomal translocation, the GAS5-BCL6 chimeric transcripts were expressed, in which the 5'-terminal oligopyrimidine (5'TOP) sequence of GAS5 was fused to the whole coding sequence of BCL6. The GAS5 gene on chromosome 1q25 is the second BCL6 partner, to the SNHG5 on 6q15, which is classified as a non-protein-coding multiple snoRNA host and 5'-TOP class gene.

References

Jan 1, 1991·Genes, Chromosomes & Cancer·B JohanssonF Mitelman
Dec 31, 1997·Leukemia & Lymphoma·H Ohno, S Fukuhara

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Citations

Jun 25, 2013·Cancer Letters·Xuefei ShiYong Song
Aug 24, 2010·Human Molecular Genetics·Maite Huarte, John L Rinn
Aug 29, 2013·Biochemistry. Biokhimii︠a︡·J A MakarovaA I Grigoriev
Nov 19, 2011·Cancer Discovery·John R Prensner, Arul M Chinnaiyan
Dec 15, 2010·PloS One·Carlos RiverosUNKNOWN ANZgene Multiple Sclerosis Genetics Consortium
Jul 23, 2013·International Journal of Molecular Sciences·Annalisa PacilliLorenzo Montanaro
Aug 24, 2013·International Journal of Molecular Sciences·Federica CaloreMichela Garofalo
Sep 10, 2013·International Journal of Molecular Sciences·Guorui Deng, Guangchao Sui
Jul 25, 2013·Antioxidants & Redox Signaling·Guohui WanXiongbin Lu
Oct 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mohammadreza HajjariYoung Kee Shin
Jul 23, 2015·Genes·Mark R Pickard, Gwyn T Williams
Apr 14, 2012·Biochimica Et Biophysica Acta·Kaiissar MannoorFeng Jiang
Dec 31, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Li PengGuan-Cheng Li
Feb 24, 2009·Gene·Giuseppe TortorielloMaria Furia
Mar 12, 2016·Cancer Letters·Ailin ZhangHong Yang
Dec 5, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chenhui MaYong Song
Nov 28, 2015·Briefings in Functional Genomics·Norma I Rodríguez-Malavé, Dinesh S Rao
Apr 10, 2016·Cellular Oncology (Dordrecht)·V TaucherJ Haybaeck
Nov 26, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Nithyananda Thorenoor, Ondrej Slaby
Mar 18, 2015·Bioinformatics·Saakshi JalaliVinod Scaria
Apr 24, 2016·Nucleic Acids Research·Natasha S Latysheva, M Madan Babu
Aug 2, 2016·The Journal of Clinical Investigation·Joseph R EvansArul M Chinnaiyan
Sep 9, 2016·Bioinformatics·Xiaowei ChenRunsheng Chen
Dec 23, 2016·Nature Communications·Nkerorema Djodji DamasAnders H Lund
Jul 4, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wenwu YangLi Jiang
Feb 2, 2018·Genes·Lucia NobiliAntonino Neri
May 5, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Qirong WenXiujie Sheng
Jun 18, 2019·Journal of Cellular Physiology·Wenwu YangLi Jiang
Nov 22, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lianmei ZhaoJuan Shi
Sep 28, 2017·Oncotarget·Lucia NobiliAntonino Neri
Nov 20, 2016·Oncotarget·Yongbin ZhengShilun Tong
May 14, 2016·Oncotarget·Lucia NobiliAntonino Neri
Feb 18, 2020·Histochemistry and Cell Biology·Xian-Ru XiaGuo-Lin Yuan
Jan 12, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Graziella Ribeiro de SousaElvis Terci Valera
Aug 6, 2020·OncoTargets and Therapy·Wei HanWei Guan
Feb 7, 2018·Acta Biochimica Et Biophysica Sinica·Huijun ShenYing Zhang
Jun 18, 2017·Biochemical Society Transactions·Zhi Hao Kwok, Yvonne Tay
Sep 25, 2018·Briefings in Functional Genomics·Xing ChenJian-Qiang Li
Apr 10, 2017·Molecular Biology Reports·Arunagiri Kuha Deva Magendhra RaoSamson Mani

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