PMID: 2494802Jan 1, 1989Paper

The gastric mucosal barrier: tight junction structure in gastritis and ulcer biopsies

Virchows Archiv. A, Pathological Anatomy and Histopathology
Z PosalakyR A Meyer

Abstract

Tight junctions of the human gastric mucosa were examined using quantitative freeze-fracture methods. Biopsies examined were from patients with gastric diseases including gastritis, ulcers, and pernicious anemia. No significant differences were seen in strand number or tight junction complex depth among the biopsies analyzed, however, anomalous tight junction structures were observed. Discontinuities in the tight junctions complex and hyperplastic tight junctions (extensions of the apical tight junction strands radiating over the lateral plasma membrane) were seen. These alterations were not associated exclusively with either the diagnosis of gastritis or ulcers. However, a higher frequency of tight junction breaks was seen in stomach biopsies diagnosed as gastritis while those diagnosed as ulcers displayed a higher occurrence of hyperplastic tight junctions.

References

Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·R A MeyerZ Posalaky
Aug 1, 1986·Gastroenterology·R A MeyerZ Posalaky
Aug 1, 1973·The Journal of Cell Biology·P Claude, D A Goodenough
Jan 1, 1974·International Review of Cytology·L A Staehelin
Jun 8, 1967·The New England Journal of Medicine·H W Davenport
Feb 1, 1984·Journal of Ultrastructure Research·R A MeyerZ Posalaky
Jul 31, 1981·Science·B Kachar, P Pinto da Silva

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Citations

Oct 1, 1995·Scandinavian Journal of Gastroenterology·H Sørbye, K Svanes
Jan 13, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·P L BardonnetF Falson
Dec 26, 2001·Journal of Pediatric Gastroenterology and Nutrition·Tamara Matysiak-Budnik, Martine Heyman

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