The gastric mucosal protective effects of astragaloside IV in mnng-induced GPL rats

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Tiantian CaiXiaohui Zeng

Abstract

Gastric Cancer is one of the most common types of cancer. And the occurrence of gastric carcinoma is an evolutionary histopathological stage. As a result, further research of GPL, which is a borderline of gastric cancer, is indispensable for preventing the formation and development of gastric carcinoma. Several studies have demonstrated a correlation between the expression of autophagy, apoptosis and Gastric cancer (GC). However, the effects of autophagy and apoptosis on human gastric cancer progression, particularly on gastric precancerous lesions (GPL), have not totally been investigated. At present, Astragaloside IV(AS-IV) is a saponin purified from Astragalus membranaceous Bge, a traditional Chinese herb that has been widely used for more than 2000 y in the treatment of cancer, cardiovascular and immune disorders. This study was designed to investigate the mechanism of AS-IV protecting gastric mucosa in N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced GPL rats. The lesions of GIM and GED were significantly ameliorated compared with the model rats, especially crowded tubular glandular and back-to-back tubular structure, which were the dangerous borderline between GPL and GC. Western Blot analysis showed that the ratio of ...Continue Reading

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Citations

Apr 20, 2019·International Journal of Molecular Sciences·Hao ShanMin Li
Nov 21, 2019·BMC Complementary and Alternative Medicine·Wei LiuLi-Zhu Lin
Jul 2, 2020·Drug Design, Development and Therapy·Danyan LiShengsheng Zhang
May 27, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Liangjun YangHuafeng Pan
Oct 28, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tiantian CaiHuafeng Pan
Jun 15, 2021·Immunopharmacology and Immunotoxicology·Wei LiuDongsheng Wang
Jul 2, 2021·BioMed Research International·Sheng-Yu LuYan Cui
Aug 20, 2021·Frontiers in Cell and Developmental Biology·Lin-Lin ZhangYu Zhu

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