The gastrin gene promoter is regulated by p73 isoforms in tumor cells

Oncogene
K TomkovaAlexander I Zaika

Abstract

p73, a new p53 family member, is a transcription factor that is increasingly recognized in cancer research as an important player in tumorigenesis as well as in chemotherapeutic drug sensitivity. Despite the substantial structural and functional similarities to p53, accumulating evidence suggests that p53 and p73 may differently regulate their transcriptional targets. In this study, we have investigated the role of p73 in regulation of the gastrin gene promoter. Gastrin is a peptide hormone and an important factor in determining the progression of a number of human malignancies. Our results show that p73 can bind to the gastrin promoter. This leads to transcriptional upregulation of gastrin mRNA. We also found that the levels of gastrin and p73 transcripts correlate in primary gastric tumors. Taken together, our results demonstrate a novel mechanism for regulation of gastrin gene transcription and support a concept that p53 and p73 may have different biological roles in tumors.

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Citations

Jul 10, 2008·Nucleic Acids Research·Wen Hong TohKanaga Sabapathy
Sep 6, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Elena ZaikaAlexander I Zaika
Dec 17, 2008·Cancer Research·Wooin LeeWael El-Rifai
Mar 4, 2010·Molecular Cancer Therapeutics·Anna E VilgelmAlexander I Zaika
Dec 24, 2013·Journal of Molecular Endocrinology·Lin XiaoOneel Patel
Feb 5, 2010·British Journal of Neurosurgery·J CaoZ S Huang
Sep 20, 2008·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Anna VilgelmAlexander Zaika
Aug 19, 2007·Cancer Letters·Anna M Grabowska, Susan A Watson
Feb 23, 2020·International Journal of Molecular Sciences·Chao WangKanaga Sabapathy

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