The gastro-entero-pancreatic hormone response to fasting in obesity

Diabetologia
W J AndrewsK D Buchanan

Abstract

A comparison of the metabolic and gastroentero-pancreatic hormonal responses of ten obese and eight lean subjects to 12 h and 36 h fasts has been made. Each subject was given a 50 g oral glucose tolerance test at the end of both 12 h and 36 h starvation. After the 12 h fast blood glucose and 3-hydroxybuty-rate were similar in each group but blood glycerol was 30% higher in the obese subjects. Plasma insulin and vaso-active intestinal polypeptide were also higher in the obese subjects after 12 h starvation. After 36 h starvation in the lean subjects blood glucose was unchanged but on refeeding with 50 g oral glucose, glucose tolerance was impaired. In the same group blood glycerol and 3-hydroxybutyrate rose after 36 h starvation. Plasma glucagon, secretin and vaso-active intestinal polypeptide rose after 36 h starvation in the lean subjects but plasma insulin was unchanged. Refeeding with oral glucose suppressed the increased plasma glucagon, secretin and vaso-active intestinal polypeptide. After the 36 h fast in the obese subjects, blood glucose was unchanged, blood glycerol fell, but blood 3-hydroxybutyrate rose although to a reduced level in comparison with the lean subjects. In the obese group there was no change in plasma g...Continue Reading

Citations

Jan 1, 1983·European Journal of Applied Physiology and Occupational Physiology·O OktedalenO B Schaffalitzky de Muckadell
Aug 1, 1988·Mayo Clinic Proceedings·L T ShusterF J Service
Feb 28, 2001·Diabetes, Obesity & Metabolism·B BaranowskaM Borowiec
Feb 24, 2001·Annals of the New York Academy of Sciences·B BaranowskaM Borowiec

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