The gaussian curvature elastic modulus of N-monomethylated dioleoylphosphatidylethanolamine: relevance to membrane fusion and lipid phase behavior

Biophysical Journal
D P Siegel, Michael M Kozlov

Abstract

The energy of intermediates in fusion of phospholipid bilayers is sensitive to kappa(m), the saddle splay (Gaussian curvature) elastic modulus of the lipid monolayers. The value kappa(m) is also important in understanding the stability of inverted cubic (Q(II)) and rhombohedral (R) phases relative to the lamellar (L(alpha)) and inverted hexagonal (H(II)) phases in phospholipids. However, kappa(m) cannot be measured directly. It was previously measured by observing changes in Q(II) phase lattice dimensions as a function of water content. Here we use observations of the phase behavior of N-mono-methylated dioleoylphosphatidylethanolamine (DOPE-Me) to determine kappa(m). At the temperature of the L(alpha)/Q(II) phase transition, T(Q), the partial energies of the two phases are equal, and we can express kappa(m) in terms of known lipid monolayer parameters: the spontaneous curvature of DOPE-Me, the monolayer bending modulus kappa(m), and the distance of the monolayer neutral surface from the bilayer midplane, delta. The calculated ratio kappa(m)/kappa(m) is -0.83 +/- 0.08 at T(Q) approximately 55 degrees C. The uncertainty is due primarily to uncertainty in the value of delta for the L(alpha) phase. This value of kappa(m)/kappa(m) ...Continue Reading

References

Oct 1, 1992·Biophysical Journal·C NanavatiJ M Fernandez
May 2, 1989·Biochemistry·H EllensJ Bentz
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D M AndersonS Leibler
Aug 15, 1994·Biochemical and Biophysical Research Communications·R M Epand, R F Epand
Dec 1, 1995·Biophysical Journal·Y A ChizmadzhevJ Zimmerberg
Jun 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·P I KuzminF S Cohen
Jan 25, 2002·Biophysical Journal·Vladislav S Markin, Joseph P Albanesi
Jan 25, 2002·Biophysical Journal·Yonathan Kozlovsky, Michael M Kozlov
Apr 4, 2002·Traffic·Michael M Kozlov, Leonid V Chernomordik
Jul 9, 2002·Biochimica Et Biophysica Acta·Xiaoyuan Wang, Peter J Quinn
Sep 14, 2002·Science·Lin Yang, Huey W Huang
Dec 24, 2002·Biophysical Journal·Sylvio May
Mar 1, 2003·Biophysical Journal·Lin Yang, Huey W Huang
Oct 17, 2003·Biochimica Et Biophysica Acta·Richard M EpandEllen Wachtel
Jan 16, 2004·The Journal of Membrane Biology·V CherezovM Caffrey
Jan 28, 2004·Magnetic Resonance in Chemistry : MRC·Richard M EpandDonald W Hughes

❮ Previous
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Citations

Oct 30, 2009·The Journal of Membrane Biology·Meyer B Jackson
Mar 6, 2013·Biomechanics and Modeling in Mechanobiology·Luca Deseri, Giuseppe Zurlo
Aug 12, 2009·Journal of Biological Physics·Ernesto Hernández-ZapataIván Santamaría-Holek
Apr 30, 2014·Current Opinion in Solid State & Materials Science·Nathan W Schmidt, Gerard C L Wong
Apr 9, 2011·Journal of the American Chemical Society·Nathan W SchmidtGerard C L Wong
Aug 19, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Chandrashekhar V Kulkarni
Dec 25, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Sergey A DergunovEugene Pinkhassik
Dec 21, 2005·Nature Reviews. Molecular Cell Biology·Joshua Zimmerberg, Michael M Kozlov
Jul 4, 2008·Nature Structural & Molecular Biology·Leonid V Chernomordik, Michael M Kozlov
Feb 9, 2010·Nature Structural & Molecular Biology·Geert van den BogaartReinhard Jahn
Sep 16, 2006·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·John M SeddonRichard H Templer
Sep 8, 2006·The European Physical Journal. E, Soft Matter·J-M Allain, M Ben Amar
Apr 21, 2009·PMC Biophysics·Guillaume Tresset
May 8, 2007·PLoS Computational Biology·Tristan UrsellRob Phillips
Nov 26, 2009·PLoS Computational Biology·Gur FabrikantMichael M Kozlov
Oct 25, 2012·PLoS Computational Biology·Bartosz RóżyckiGerhard Hummer
Dec 2, 2009·The Journal of Chemical Physics·Wouter K den Otter
Apr 26, 2013·The Journal of Chemical Physics·F A M Leermakers
Apr 3, 2012·Annual Review of Biochemistry·Felix Campelo, Vivek Malhotra
Apr 2, 2014·Advances in Colloid and Interface Science·Isabelle MartielRaffaele Mezzenga
Mar 5, 2015·Life·Yuka Sakuma, Masayuki Imai
Oct 20, 2009·FEBS Letters·Felix CampeloMichael M Kozlov
Jan 15, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Toshihiko OkaMasahito Yamazaki
Feb 5, 2015·Biophysical Journal·Tao ZhangJ M Schwarz
Aug 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·Hongwei YaoMei Hong
Apr 17, 2012·Progress in Lipid Research·Félix M GoñiAlicia Alonso
Feb 22, 2012·Journal of Theoretical Biology·M MerckerW Jäger
Jul 20, 2010·Trends in Biochemical Sciences·Michael M KozlovLeonid V Chernomordik
Mar 15, 2016·Biochimica Et Biophysica Acta·A WestJ N Sachs
Oct 19, 2006·Chemistry and Physics of Lipids·Derek Marsh
May 28, 2013·Biophysical Journal·Alexander J Sodt, Richard W Pastor
Aug 8, 2014·Biophysical Journal·Padmini RangamaniGeorge Oster
Jun 22, 2015·European Biophysics Journal : EBJ·L Martínez-BalbuenaI Santamaría-Holek
Jun 5, 2008·Current Biology : CB·Anna ShnyrovaJoshua Zimmerberg
Feb 28, 2013·Biophysical Journal·Huan Zhan, Themis Lazaridis
Sep 30, 2004·Biophysical Journal·Yonathan KozlovskyMichael M Kozlov
Jun 28, 2008·Biochimica Et Biophysica Acta·Andrea HickelGeorg Pabst
May 17, 2005·Biophysical Journal·T BaumgartJ T Jenkins

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