PMID: 11544105Sep 7, 2001Paper

The GDNF/RET signaling pathway and human diseases

Cytokine & Growth Factor Reviews
M Takahashi

Abstract

Glial cell line-derived neurotrophic factor (GDNF) and related molecules, neurturin, artemin and persephin, signal through a unique multicomponent receptor system consisting of RET tyrosine kinase and glycosyl-phosphatidylinositol-anchored coreceptor (GFRalpha1-4). These neurotrophic factors promote the survival of various neurons including peripheral autonomic and sensory neurons as well as central motor and dopamine neurons, and have been expected as therapeutic agents for neurodegenerative diseases. In addition, it turned out that the GDNF/RET signaling plays a crucial role in renal development and regulation of spermatogonia differentiation. RET mutations cause several human diseases such as papillary thyroid carcinoma, multiple endocrine neoplasia types 2A and 2B, and Hirschsprung's disease. The mutations resulted in RET activation or inactivation by various mechanisms and the biological properties of mutant proteins appeared to be correlated with disease phenotypes. The signaling pathways activated by GDNF or mutant RET are being extensively investigated to understand the molecular mechanisms of disease development and the physiological roles of the GDNF family ligands.

References

Jul 1, 1992·Japanese Journal of Cancer Research : Gann·W WajjwalkuM Takahashi
May 1, 1992·The Journal of Clinical Investigation·M SantoroN Berger
Apr 1, 1990·Japanese Journal of Cancer Research : Gann·M NagaoT Sugimura
Dec 1, 1989·Japanese Journal of Cancer Research : Gann·Y IshizakaM Nagao
Apr 1, 1987·Molecular and Cellular Biology·M Takahashi, G M Cooper
May 1, 1995·Human Molecular Genetics·M AngristA Chakravarti
May 1, 1995·Nature Genetics·B PasiniR Bocciardi
Sep 15, 1995·The Journal of Biological Chemistry·A PandeyV M Dixit
Dec 1, 1994·Human Molecular Genetics·L M MulliganA Safar
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·K M CarlsonH Donis-Keller
Jul 1, 1993·Human Molecular Genetics·H Donis-KellerS A Wells
Jun 27, 1996·Nature·P DurbecM Saarma
Jul 4, 1996·Nature·M W MooreA Rosenthal
Jul 4, 1996·Nature·J J TreanorA Rosenthal
Oct 1, 1996·Human Molecular Genetics·T IwashitaM Takahashi
Jan 1, 1996·Advances in Cancer Research·B A Ponder, D Smith
Jan 3, 1997·The Journal of Biological Chemistry·D H van Weering, J L Bos
Feb 20, 1997·Oncogene·E ArighiM G Borrello
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·F M MichielsM Billaud
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·M SanicolaR L Cate
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·D J CreedonE M Johnson

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Citations

Aug 11, 2011·Inflammatory Bowel Diseases·Shunsuke SaitoKazuhide Yamamoto
Jan 6, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Macarena Ruiz-FerrerSalud Borrego
Sep 16, 2004·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ken-ichi NibuJay L Rothstein
Jan 19, 2013·Apoptosis : an International Journal on Programmed Cell Death·Minakshi MazumdarTanya Das
May 29, 2013·Cellular and Molecular Neurobiology·Chetan Lakshmana ReddyEroboghene E Ubogu
May 11, 2005·Familial Cancer·Christian A Koch
Jun 2, 2007·Journal of Molecular Histology·Mihail E HinescuLaurentziu M Popescu
Oct 6, 2007·Endocrine Pathology·Andrea Z LaiLois M Mulligan
Jun 12, 2002·Biochemical and Biophysical Research Communications·Naoko IwahashiMasahide Takahashi
Mar 12, 2004·Cancer Letters·Masatoshi IchiharaMasahide Takahashi
Jul 16, 2003·Gastroenterology Clinics of North America·D Scott SmithChristopher D Ferris
Jun 18, 2003·Respiratory Physiology & Neurobiology·David M Katz
Sep 4, 2012·Acta Pharmacologica Sinica·Wei-Feng MaoChong-Gang Yuan
Jul 13, 2011·Cell Research·Jiyoung Lee, Takashi Shinohara
Dec 14, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Daniel D MillerMeera Mahalingam
Mar 19, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zhigang ZhouMarina Mata
Oct 5, 2006·Nature Clinical Practice. Oncology·Matthias Drosten, Brigitte M Pützer
Sep 24, 2011·Nature Reviews. Cancer·Aditi A BapatHaiyong Han
May 4, 2002·Nature Reviews. Neuroscience·Matti S Airaksinen, Mart Saarma
May 2, 2007·Oncogene·S DonatelloM G Borrello
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nobutaka OhgamiMasashi Kato
Jul 21, 2005·Thyroid : Official Journal of the American Thyroid Association·Maria A KouvarakiDouglas B Evans
Jul 9, 2004·Journal of the National Cancer Institute·Giuditta CuccuruFranco Zunino
Aug 19, 2004·Journal of the National Cancer Institute·Matthias DrostenBrigitte M Pützer
Aug 14, 2013·Journal of the National Cancer Institute·Ivana JochmanováKarel Pacak
Nov 17, 2006·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Macarena Ruiz-FerrerSalud Borrego
Jul 22, 2006·Annals of Surgery·Güralp O CeyhanHelmut Friess
Feb 22, 2012·Current Opinion in Oncology·Madson Q Almeida, Ana O Hoff
Feb 3, 2006·Genes & Development·Sanjay JainJeffrey Milbrandt
Apr 26, 2006·Pathology International·Naoya AsaiMasahide Takahashi
Oct 17, 2002·Annals of the New York Academy of Sciences·Christian A KochKarel Pacak
Sep 20, 2006·Molecular and Cellular Biology·Matthew J SmithTony Pawson
Sep 2, 2004·Molecular and Cellular Biology·Mayumi JijiwaMasahide Takahashi
Oct 18, 2005·Molecular and Cellular Biology·Adrianne WongVassilis Pachnis
Feb 22, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tinamarie LieuBradley J Undem
Sep 11, 2009·American Journal of Physiology. Renal Physiology·Sunder Sims-LucasCarlton M Bates
Jun 4, 2011·Journal of Signal Transduction·Renfang SongIhor V Yosypiv
Sep 4, 2003·The Journal of Clinical Investigation·Jari RossiMatti S Airaksinen

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