PMID: 11544105Sep 7, 2001Paper

The GDNF/RET signaling pathway and human diseases

Cytokine & Growth Factor Reviews
M Takahashi


Glial cell line-derived neurotrophic factor (GDNF) and related molecules, neurturin, artemin and persephin, signal through a unique multicomponent receptor system consisting of RET tyrosine kinase and glycosyl-phosphatidylinositol-anchored coreceptor (GFRalpha1-4). These neurotrophic factors promote the survival of various neurons including peripheral autonomic and sensory neurons as well as central motor and dopamine neurons, and have been expected as therapeutic agents for neurodegenerative diseases. In addition, it turned out that the GDNF/RET signaling plays a crucial role in renal development and regulation of spermatogonia differentiation. RET mutations cause several human diseases such as papillary thyroid carcinoma, multiple endocrine neoplasia types 2A and 2B, and Hirschsprung's disease. The mutations resulted in RET activation or inactivation by various mechanisms and the biological properties of mutant proteins appeared to be correlated with disease phenotypes. The signaling pathways activated by GDNF or mutant RET are being extensively investigated to understand the molecular mechanisms of disease development and the physiological roles of the GDNF family ligands.


Jul 1, 1992·Japanese Journal of Cancer Research : Gann·W WajjwalkuM Takahashi
May 1, 1992·The Journal of Clinical Investigation·M SantoroN Berger
Apr 1, 1990·Japanese Journal of Cancer Research : Gann·M NagaoT Sugimura
Dec 1, 1989·Japanese Journal of Cancer Research : Gann·Y IshizakaM Nagao
Apr 1, 1987·Molecular and Cellular Biology·M Takahashi, G M Cooper
May 1, 1995·Human Molecular Genetics·M AngristA Chakravarti
May 1, 1995·Nature Genetics·B PasiniR Bocciardi
Sep 15, 1995·The Journal of Biological Chemistry·A PandeyV M Dixit
Dec 1, 1994·Human Molecular Genetics·L M MulliganA Safar
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·K M CarlsonH Donis-Keller
Jul 1, 1993·Human Molecular Genetics·H Donis-KellerS A Wells
Jun 27, 1996·Nature·P DurbecM Saarma
Jul 4, 1996·Nature·M W MooreA Rosenthal
Jul 4, 1996·Nature·J J TreanorA Rosenthal
Oct 1, 1996·Human Molecular Genetics·T IwashitaM Takahashi
Jan 1, 1996·Advances in Cancer Research·B A Ponder, D Smith
Jan 3, 1997·The Journal of Biological Chemistry·D H van Weering, J L Bos
Feb 20, 1997·Oncogene·E ArighiM G Borrello
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·F M MichielsM Billaud
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·M SanicolaR L Cate
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·D J CreedonE M Johnson

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