PMID: 37541Apr 11, 1979

The Geller-Seifter conflict paradigm with incremental shock

Psychopharmacology
G T Pollard, J L Howard

Abstract

The typical Geller-Seifter conflict paradigm for predicting clinical efficacy of anxiolytics is a mult VI/CRF schedule in which response rates in the CRF (conflict) portion are depressed by response-contingent electric shock. In 1-h sessions, anxiolytics raise the depressed conflict rates. Recently it was shown that replacing the single shock level with an arrangement whereby shock begins at zero and is increased with each response in the conflict portion produced more orderly data and facilitated training and maintenance of experimental subjects; chlordiazepoxide was the test drug. In the present study, those results are replicated in 30-min sessions, and the incremental paradigm is demonstrated to be as specific for anxiolytics as the standard Geller-Seifter paradigm. The possibility of very short sessions is suggested.

References

Apr 1, 1977·Physiology & Behavior·G T PollardJ L Howard
Jan 1, 1971·Psychopharmacologia·J R VogelD E Clody
Jan 1, 1969·Psychopharmacologia·P C DandiyaS K Patni
Apr 1, 1962·Journal of Comparative and Physiological Psychology·H BARRY, N E MILLER

Citations

Jan 1, 1984·Psychopharmacology·S Aston-JonesG F Koob
Jan 1, 1982·Psychopharmacology·J L HowardG T Pollard
Oct 20, 1992·European Journal of Pharmacology·G T PollardJ L Howard
Dec 1, 1983·Neuropharmacology·H Lal, M W Emmett-Oglesby
Oct 1, 1982·Pharmacology, Biochemistry, and Behavior·J B Patel, B Migler
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·A Meneses, E Hong
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·D Treit
Jan 1, 1990·Pharmacology & Therapeutics·G T Pollard, J L Howard
Dec 30, 1986·Regulatory Peptides·K Thatcher-Britton, G F Koob
Jan 1, 1984·Psychoneuroendocrinology·J F Rodriguez-SierraS E Hendricks
Sep 1, 1997·Pharmacology, Biochemistry, and Behavior·R L Smith, R J Barrett
May 30, 2002·Neuroscience and Biobehavioral Reviews·Ants KaskRémi Quirion
Aug 1, 1991·Alcoholism, Clinical and Experimental Research·H A BaldwinG F Koob
Jan 10, 2008·Genes, Brain, and Behavior·L C Milner, J C Crabbe
May 28, 2016·Journal of Alzheimer's Disease : JAD·Alexandre V IvachtchenkoIlya Okun

Related Concepts

Benzodiazepines
Thorazine
Conflict (Psychology)
Oxydess
Electroconvulsive Shock
Meprospan
Morphine Sulfate (2: 1), Pentahydrate
Diabutal
Anti-Anxiety Effect

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