The gene encoding SMR1, a precursor-like polypeptide of the male rat submaxillary gland, has the same organization as the preprothyrotropin-releasing hormone gene

DNA and Cell Biology
I Rosinski-Chupin, F Rougeon

Abstract

SMR1 is a precursor-like polypeptide of the submaxillary glands of rats. Sequence analysis predicts that it could be processed by maturation enzymes to release a small peptide resembling the thyrotropin-releasing hormone. The SMR1 gene was isolated from a rat genomic library and sequenced. The SMR1 gene spans 4.7 kb and consists of three exons. The two introns occur a few nucleotides before the initiation codon in the 5' untranslated region, and a few nucleotides before the first predicted processing site, respectively. Such a structure is reminiscent of that of the preprothyrotropin-releasing hormone gene. The site of transcriptional initiation of the SMR1 gene was determined and 1.4 kb of 5'-flanking sequence was sequenced. The sequence analysis revealed the presence of alternating purine-pyrimidine tracts and of purine-rich sequences. In addition, some sequences which could be involved in the regulation of SMR1 gene expression were identified.

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Citations

Feb 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·I Rosinski-ChupinT Serikawa
Aug 11, 1991·Nucleic Acids Research
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Aug 8, 2020·The Journal of Pharmacology and Experimental Therapeutics·Takugi KanToshiyasu Suzuki
Dec 26, 2008·American Journal of Physiology. Cell Physiology·K E MorrisA D Befus

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