The gene PatG involved in the biosynthesis pathway of patulin, a food-borne mycotoxin, encodes a 6-methylsalicylic acid decarboxylase

International Journal of Food Microbiology
Selma P SniniOlivier Puel

Abstract

Patulin is a mycotoxin produced by fungal genera such as Aspergillus, Penicillium and Byssochlamys. It induces neurological, gastrointestinal and immunological effects, which is why patulin belongs to a short list of mycotoxins whose level in food is regulated in many countries around the world. Recently, a cluster gathering 15 genes involved in the biosynthesis of patulin has been identified in Aspergillus clavatus, but so far, only 4 genes encoding 6-methylsalicylic acid synthase, m-cresol hydroxylase, m-hydroxybenzyl alcohol hydroxylase and isoepoxydon dehydrogenase have been characterized. Previous studies have shown the involvement of a decarboxylase in the transformation of 6-methylsalicylic acid, the first stable patulin precursor, into m-cresol. In this study a putative decarboxylase gene, PatG, was identified in the genome sequence of A. clavatus. This gene is located near two P450 cytochrome genes PatH and PatI responsible respectively for the hydroxylation of m-cresol and m-hydroxybenzyl alcohol. This decarboxylase encoded by PatG (ACLA_093620) consists of 325 amino acids. The search for putative conserved domain revealed that the gene product belongs to the AminoCarboxyMuconate Semialdehyde Decarboxylase (ACMSD) rel...Continue Reading

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Citations

Aug 15, 2014·International Journal of Food Microbiology·Joanna TannousOlivier Puel
Apr 1, 2017·Critical Reviews in Food Science and Nutrition·Joanna TannousOlivier Puel
Jan 24, 2019·Plant Disease·Megan N Biango-Daniels, Kathie T Hodge
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Boqiang LiShiping Tian
May 3, 2021·Toxicon : Official Journal of the International Society on Toxinology·Dipendra Kumar MahatoPradeep Kumar
Feb 28, 2018·Journal of Natural Products·Robert L BertrandJohn L Sorensen
Aug 24, 2021·Applied Microbiology and Biotechnology·Wei WangShu-Shan Gao

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