The generalized convulsive seizure state induced by daily electrical stimulation of the amygdala in split brain cats.

Epilepsia
J A Wada, M Sato

Abstract

Daily unilateral electrical stimulation of amygdala in forebrain bisected cats provoked the development of the final stage of the kindled convulsion with remarkable rapidity regardless of presence or absence of anterior commissure. The chronological and spatial pattern of propagation of afterdischarge, interictal spike discharge, and clinical manifestations strongly suggest the significant role played by the midbrain reticular formation and possibly other brainstem structures in the progressive electroclinical seizure development. This assumption was supported by the results of a lesion study in which placement of a destructive lesion in the ipsilateral midbrain reticular formation markedly increased the generalized seizure triggering threshold, lateralized the afterdischarge to the stimulated hemisphere when induced with increased intensity stimulation, fragmented clinical seizure manifestations, and failed to produce progression of clinical and electrographic events with prolonged daily stimulation. This is in contrast to the insignificant effect produced by a peduncular lesion. Our findings suggest that vertical (limbic-brainstem), but not horizontal (transhemispheric interlimbic) connection is critically involved in the amy...Continue Reading

References

Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R RacineS Chipashvili
Jan 1, 1973·Electroencephalography and Clinical Neurophysiology·R MutaniG Quattrocolo
Nov 27, 1972·Brain Research·R J RacineW M Burnham
Jul 1, 1969·Neurology·B J WilderR P Schmidt
Nov 1, 1969·Experimental Neurology·G V GoddardC K Leech
Jun 1, 1969·Brain Research·G Raisman
Sep 1, 1958·Journal of Neurophysiology·A KREINDLERD CHIMION
Jul 1, 1963·Journal of Neurophysiology·T J CHAMBERLAINR W GERARD
Sep 1, 1963·Archives of Neurology·R GUERRERO-FIGUEROAR G HEATH
Aug 1, 1964·Archives of Neurology·B WEIR
Aug 1, 1963·Electroencephalography and Clinical Neurophysiology·F BERGMANNJ GUTMAN
Sep 1, 1959·Journal of Neurophysiology·R POBLETEA E WALKER

❮ Previous
Next ❯

Citations

Jun 1, 1987·Metabolic Brain Disease·C L Faingold
Aug 1, 1987·Electroencephalography and Clinical Neurophysiology·J P LiebX W Song
Apr 1, 1988·Electroencephalography and Clinical Neurophysiology·H FukudaR Naquet
Oct 1, 1988·Electroencephalography and Clinical Neurophysiology·T Hiyoshi, J A Wada
Jan 1, 1985·Progress in Neuro-psychopharmacology & Biological Psychiatry·D P Cain
May 1, 1994·Pediatric Neurology·S KhannaJ G Curran
Aug 1, 1997·Electroencephalography and Clinical Neurophysiology·J A Wada, T Kudo
Feb 26, 1998·Epilepsy Research·K Hamada, J A Wada
Sep 1, 1984·The Journal of Psychology·J Gaito
Jan 1, 1976·Folia Psychiatrica Et Neurologica Japonica·J A McCaughranJ A Wada
Jan 1, 1976·Folia Psychiatrica Et Neurologica Japonica·M Sato
Jan 1, 1979·Folia Psychiatrica Et Neurologica Japonica·N TsuruJ Idenoue
Jan 1, 1980·Folia Psychiatrica Et Neurologica Japonica·M Sato
Jun 1, 1991·The Japanese Journal of Psychiatry and Neurology·J A Wada
Aug 1, 1979·Epilepsia·A R Wyler, J E Heavner
Oct 1, 1982·Epilepsia·J A WadaY Kaneko
Jul 1, 1987·Epilepsia·T Hiyoshi, J A Wada
Jun 15, 1999·Epilepsia·J A Wada, K Hamada
Jan 1, 1981·The International Journal of Neuroscience·K OnoH Baba
Jan 1, 1981·The International Journal of Neuroscience·K OnoK Mori
Dec 11, 1992·Brain Research·M R Pelletier, M E Corcoran
Feb 1, 1978·Experimental Neurology·J A McCaughranJ A Wada
Mar 1, 1988·Experimental Neurology·T Kudo, T Yamauchi
Jan 1, 1985·Experimental Neurology·D C McIntyre, G N Stuckey
Dec 1, 1984·Annals of Neurology·S S SpencerR H Mattson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.