PMID: 210249Jun 1, 1978

The generation and regulation of lymphocyte populations: evidence from differentiative induction systems in vitro

The Journal of Experimental Medicine
M P ScheidE A Boyse

Abstract

Results with a dual assay, for the induction of Thy-1+ T cells and of CR+ B cells from marker-negative precursors, confirm that thymopoietin is at present the only known selective inducer of prothymocytes. In contrast, various inducers, including ubiquitin, are active in both assays. Pharmacological evidence indicates that there are different cellular receptors for ubiquitin and thymopoietin. Prothymocytes and pro-CR+ B cells compose two distinct populations in bone marrow and spleen; their distribution in density gradients is different, and elimination of either population enriches the other proportionately. There are no noteworthy differences between induction of these two populations in regard to (a) kinetics, (b) dependence on temperature and protein synthesis, (c) activation by cAMP, and (d) inhibition by cGMP. The opposite inductive effects of cAMP and cGMP were corroborated by the use of pharmacological agents that raise or lower the levels of intracellular cyclic nucleotides. In contrast, a third induction assay, which monitors acquisition of the PC+ surface phenotype, indicates that this differentiative step, the last known for B cells, is initiated by cGMP and inhibited by cAMP. Induction of PC is also inhibited by th...Continue Reading

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Citations

Feb 28, 1975·Annals of the New York Academy of Sciences·M P ScheidE A Boyse
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Related Concepts

Poly A-U
T-Lymphocyte
Lymphoid Cells
Cell Differentiation Process
B-Lymphocytes
Medihaler-Epi
Novodrin
Cyclic AMP, (R)-Isomer
Imidazoles
Polypeptides

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