PMID: 210249Jun 1, 1978

The generation and regulation of lymphocyte populations: evidence from differentiative induction systems in vitro

The Journal of Experimental Medicine
M P ScheidE A Boyse


Results with a dual assay, for the induction of Thy-1+ T cells and of CR+ B cells from marker-negative precursors, confirm that thymopoietin is at present the only known selective inducer of prothymocytes. In contrast, various inducers, including ubiquitin, are active in both assays. Pharmacological evidence indicates that there are different cellular receptors for ubiquitin and thymopoietin. Prothymocytes and pro-CR+ B cells compose two distinct populations in bone marrow and spleen; their distribution in density gradients is different, and elimination of either population enriches the other proportionately. There are no noteworthy differences between induction of these two populations in regard to (a) kinetics, (b) dependence on temperature and protein synthesis, (c) activation by cAMP, and (d) inhibition by cGMP. The opposite inductive effects of cAMP and cGMP were corroborated by the use of pharmacological agents that raise or lower the levels of intracellular cyclic nucleotides. In contrast, a third induction assay, which monitors acquisition of the PC+ surface phenotype, indicates that this differentiative step, the last known for B cells, is initiated by cGMP and inhibited by cAMP. Induction of PC is also inhibited by th...Continue Reading


Jun 1, 1989·Cellular and Molecular Neurobiology·E L OchoaM G McNamee
Jan 1, 1981·Immunogenetics·A HatzfeldE A Boyse
Mar 1, 1981·Cell Biophysics·A J RosenspireD M Jacobs
Mar 1, 1981·Cell Biophysics·A J Rosenspire, D M Jacobs
Jun 25, 1998·Immunologic Research·V K SinghS S Agarwal
Nov 30, 1981·Biochimica Et Biophysica Acta·J B VaughnG Goldstein
Oct 23, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·P J LisiM Schiffman
Jul 1, 1983·Mechanisms of Ageing and Development·V K GhantaR N Hiramoto
Jan 1, 1984·Developmental and Comparative Immunology·K S Landreth, P W Kincade
Sep 1, 1988·Immunopharmacology·N M KouttabA L Maizel
Jul 20, 1988·Biochimica Et Biophysica Acta·A A AmoscatoG F Babcock
Jan 1, 1984·International Journal of Immunopharmacology·S W BurchielN L Warner
Jun 1, 1997·International Journal of Immunopharmacology·S BiswasS S Agarwal
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J W SchraderR Scollay
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G J FreemanH Cantor
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S S ChenJ W Hadden
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T AudhyaG Goldstein
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K VenkatasubramanianG Goldstein
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T AudhyaG Goldstein
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B A ImhofJ P Thiery
Feb 1, 1990·Scandinavian Journal of Immunology·T AudhyaG Goldstein
Nov 1, 1994·Scandinavian Journal of Immunology·F NicolettiP L Meroni
Jan 1, 1991·Annals of the New York Academy of Sciences·V K GhantaR N Hiramoto
Sep 1, 1992·Archives of Disease in Childhood·K H HsiehT N Liao
Oct 1, 1982·Annals of the Rheumatic Diseases·E M VeysJ Symoens
Feb 1, 1983·Annals of the Rheumatic Diseases·P A ThrowerE C Huskisson
Jul 1, 1983·The Journal of Experimental Medicine·R S MittlerG Goldstein


Feb 28, 1975·Annals of the New York Academy of Sciences·M P ScheidE A Boyse
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·G GoldsteinD G Gilmour
Nov 1, 1968·The Journal of Experimental Medicine·W H Lay, V Nussenzweig
Oct 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J W HaddenN D Goldberg
Aug 1, 1973·The Journal of Experimental Medicine·T B StromM Kaliner
Oct 1, 1973·The Journal of Experimental Medicine·M P ScheidA L Goldstein
Aug 1, 1973·The Journal of Experimental Medicine·K Komuro, E A Boyse
Jun 1, 1970·The Journal of Experimental Medicine·T TakahashiE A Boyse

Related Concepts

Poly A-U
Lymphoid Cells
Cell Differentiation Process
Cyclic AMP, (R)-Isomer

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.