PMID: 3748317Jun 1, 1986Paper

The generation of cortical slow potentials in the rat anaesthetised with urethane and their modification by nicotine

Neuropharmacology
I S Ebenezer

Abstract

This paper reports the generation of cortical slow potentials (SP), similar to the human contingent negative variation, in rats anaesthetised with urethane. Rats previously implanted with silver/silver chloride electrodes for recording slow potentials from the frontal cortex were anaesthetised with urethane, and given extensive associative conditioning in which a 100 msec, 70 dB tone (S1) preceded electric tail shock (S2). The S1-S2 interval was initially set at 0.5 sec, and increased over a number of training sessions to 3 sec. Negative slow potential responses developed during the interval between S1 and S2. Once the slow potential response was fully developed, it persisted without habituation during subsequent sessions. Withholding tail shock (S2) resulted in a rapid extinction of the slow potential response to S1 alone. In further experiments, rats (n = 8) that generated steady slow potentials under urethane, were injected with saline (n = 4) or nicotine (0.4 mg/kg, s.c.; n = 4), and their responses measured 0-10, 15-25 and 30-40 min after administration. While saline did not affect the magnitude of the slow potential responses compared with pre-saline control values, nicotine (0.4 mg/kg) caused significant decreases in the...Continue Reading

Citations

Dec 23, 2008·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Dong GaoXueli Sun
Feb 26, 2015·The European Journal of Neuroscience·Luka R SrejicWilliam D Hutchison
Mar 15, 2006·Neurobiology of Disease·A M AleisaK A Alkadhi
Sep 12, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Luka R SrejicMichelle M Aarts

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