PMID: 7313558Jul 1, 1981Paper

The generation of specific cytotoxic responses by human lymphocytes requires antigen and activities provided by a lymphokine supernatant

Scandinavian Journal of Immunology
H S Warren

Abstract

The requirements for the generation of specific cytotoxic responses by human lymphocytes have been investigated using as a model system the response to the ultraviolet light-killed mouse tumour P815. These requirements are antigen (P815UV) and activities provided by a human lymphokine (LK) supernatant. Cells that give rise to non-specific cytotoxicity can be separated on discontinuous Percoll density gradients after a 3-day incubation of peripheral blood leucocytes with the lymphokine supernatant. Cells from which specific cytotoxic responses can subsequently be generated in the presence of P815UV and LK sediment at a higher density.

References

Apr 1, 1978·The Australian Journal of Experimental Biology and Medical Science·H S WarrenK J Lafferty
Jan 1, 1979·Scandinavian Journal of Immunology·H S Warren, K J Lafferty
Oct 1, 1979·The Australian Journal of Experimental Biology and Medical Science·J A WoolnoughK J Lafferty
Jan 1, 1979·Scandinavian Journal of Immunology·E SakselaK Cantell
Dec 15, 1977·Nature·G TrinchieriB B Knowles
Sep 1, 1967·The Journal of Experimental Medicine·R I Mishell, R W Dutton
Dec 1, 1980·The Australian Journal of Experimental Biology and Medical Science·K J LaffertyE Reich
Jan 1, 1980·Immunological Reviews·K J LaffertyS J Prowse
Jan 1, 1981·Journal of Immunological Methods·H S Warren, R G Pembrey
Jan 1, 1980·Journal of Immunological Methods·T Timonen, E Saksela

Related Concepts

Antigens
Cell Separation
Centrifugation, Density Gradient
Immunologic Tumoricidal Activities
Dose-Response Relationship, Immunologic
Lymphoid Cells
Lymphokines
Mice, Inbred DBA

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