PMID: 6170047Jan 1, 1981Paper

The genes of human hemoglobins and their expression (author's transl)

Nouvelle Revue Française D'hématologie
J Rosa

Abstract

The present report reviews the knowledge on the structure of the genes coding for the various embryonic fetal and adult chains of normal human hemoglobins. The various molecular lesions found until now in alpha- and beta-thalassemias and also in hereditary persistance of fetal hemoglobin (HPHF). During the structural studies an unexpected DNA polymorphism has been detected. This polymorphism can be used in some cases of antenatal diagnosis either of sickle cell or of some thalassemias. The method developed can be applied to studies of population genetic.

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