The genetic analysis of distributive segregation in Drosophila melanogaster. I. Isolation and characterization of Aberrant X segregation (Axs), a mutation defective in chromosome partner choice.

Genetics
A E Zitron, R S Hawley

Abstract

We describe the isolation and characterization of Aberrant X segregation (Axs), a dominant female-specific meiotic mutation. Although Axs has little or no effect on the frequency or distribution of exchange, or on the disjunction of exchange bivalents, nonexchange X chromosomes undergo nondisjunction at high frequencies in Axs/+ and Axs/Axs females. This increased X chromosome nondisjunction is shown to be a consequence of an Axs-induced defect in distributive segregation. In Axs-bearing females, fourth chromosome nondisjunction is observed only in the presence of nonexchange X chromosomes and is argued to be the result of improper X and fourth chromosome associations within the distributive system. In XX females bearing a compound fourth chromosome, the frequency of nonhomologous disjunction of the X chromosomes from the compound fourth chromosome is shown to account for at least 80% of the total X nondisjunction observed. In addition, Axs diminishes or ablates the capacity of nonexchange X chromosomes to form trivalents in females bearing either a Y chromosome or a small free duplication for the X. Axs also impairs compound X from Y segregation. The effect of Axs on these segregations parallels the defects observed for homolo...Continue Reading

Citations

Sep 1, 1993·Trends in Genetics : TIG·R S Hawley, W E Theurkauf
Nov 23, 2012·G3 : Genes - Genomes - Genetics·Kimberly A CollinsR Scott Hawley
Jul 4, 2006·Genetics·Youbin Xiang, R Scott Hawley
Mar 27, 2002·Journal of Bacteriology·María Cervantes, Francisco J Murillo
Oct 18, 2020·Chromosoma·Emily R WesleyKatherine Kretovich Billmyre
Mar 22, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·S ApionishevR S Rasooly
Jul 28, 2010·Genetics·Yong ZengWilliam D Gilliland
Nov 4, 2008·Developmental Biology·William D GillilandR Scott Hawley
Nov 15, 2008·PLoS Genetics·Vijayalakshmi V Subramanian, Sharon E Bickel

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