PMID: 8976282Jan 1, 1997Paper

The genetic and bacteriological aspects of Peyronie's disease

The Journal of Urology
David J RalphG F Bottazzo

Abstract

Peyronie's disease has been associated with HLA tissue types, including HLA-A1, DR3, DQw2 and HLA-B7 cross-reactive group antigens which include HLA-B27. This association was tested as was the process of molecular mimicry where the host HLA surface antigen cross-reacts with a microorganism. HLA tissue typing was performed on 51 white patients with Peyronie's disease, of whom 15 also had Dupuytren's contracture of the hand. Fecal, urine and urethral samples were taken from patients with Peyronie's disease who had proved penile inflammation on biopsy. The samples were cultured for species of Campylobacter, Shigella, Salmonella, Yersinia, Chlamydia and gonococcus, all known to cross-react with the HLA-B27 surface antigen. Antibodies to Klebsiella species, Proteus species and Escherichia coli were also assessed in the sera of 65 patients with Peyronie's disease. A significant association between Peyronie's disease and HLA-B27 was found (p = 0.02). The remaining antigens of the HLA-B7 group were not significantly associated with the disease individually (HLA-B7 p > 0.2, HLA-B22 p > 0.6, HLA-B40 p > 0.7) or as a group (p = 0.69). The previously found associations did not reach significance in this study (HLA-A1 p > 0.5, HLA-B8 p > 0....Continue Reading

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Citations

Nov 16, 2004·Current Urology Reports·Mark JalkutJacob Rajfer
Jun 3, 2011·International Journal of Impotence Research·H M NugterenM F van Driel
Mar 14, 2002·BJU International·U SchwarzerU Engelmann
Jun 28, 2006·Sexual Health·Bhushan KumarMadhu Gulati
Dec 12, 2012·Journal of Clinical Imaging Science·Kiriaki KalokairinouAristomenis Gekas
Jun 2, 2016·Therapeutic Advances in Urology·Elizabeth J TraoreWayne J G Hellstrom
Sep 23, 2003·The Journal of Urology·Ekkehard W HauckHolger Hackstein
Apr 1, 2004·Expert Review of Pharmacoeconomics & Outcomes Research·Luca Incrocci
Nov 28, 2002·International Journal of Impotence Research·F SommerU Engelmann
Nov 28, 2002·International Journal of Impotence Research·R B Moreland, A Nehra
Dec 6, 2001·Current Opinion in Urology·G H Lischer, A Nehra

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