The genetic and environmental determinants of the association between brain abnormalities and schizophrenia: the schizophrenia twins and relatives consortium.

Biological Psychiatry
Neeltje E M van HarenRené S Kahn

Abstract

Structural brain abnormalities are consistently found in schizophrenia (Sz) and have been associated with the familial risk for the disorder. We aim to define the relative contributions of genetic and nongenetic factors to the association between structural brain abnormalities and Sz in a uniquely powered cohort (Schizophrenia Twins and Relatives consortium). An international multicenter magnetic resonance imaging collaboration was set up to pool magnetic resonance imaging scans from twin pairs in Utrecht (The Netherlands), Helsinki (Finland), London (United Kingdom), and Jena (Germany). A sample of 684 subjects took part, consisting of monozygotic twins (n = 410, with 51 patients from concordant and 52 from discordant pairs) and dizygotic twins (n = 274, with 39 patients from discordant pairs). The additive genetic, common, and unique environmental contributions to the association between brain volumes and risk for Sz were estimated by structural equation modeling. The heritabilities of most brain volumes were significant and ranged between 52% (temporal cortical gray matter) and 76% (cerebrum). Heritability of cerebral gray matter did not reach significance (34%). Significant phenotypic correlations were found between Sz and ...Continue Reading

References

Nov 1, 1976·The Journal of Nervous and Mental Disease·J J Bartko, W T Carpenter
Sep 19, 1987·British Medical Journal·R M Murray, S W Lewis
Oct 17, 1987·British Medical Journal·J L Waddington, H A Youssef
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Mar 1, 1994·Journal of Computer Assisted Tomography·D L CollinsA C Evans
Apr 1, 1997·IEEE Transactions on Medical Imaging·F MaesP Suetens
Jun 9, 1998·IEEE Transactions on Medical Imaging·J G SledA C Evans
Feb 20, 1999·Archives of General Psychiatry·A G CardnoR M Murray
Jan 5, 2000·The American Journal of Psychiatry·I C WrightE T Bullmore
Feb 7, 2001·Archives of General Psychiatry·W F BaaréR S Kahn
Feb 2, 2002·The American Journal of Psychiatry·Hilleke E Hulshoff PolRené S Kahn
Jul 26, 2002·Briefings in Bioinformatics·Frühling V Rijsdijk, Pak C Sham
Sep 5, 2002·American Journal of Medical Genetics·Colm McDonaldRobin M Murray
Dec 10, 2003·Archives of General Psychiatry·Patrick F SullivanMichael C Neale
Jun 18, 2004·Human Brain Mapping·Hugo G SchnackRené S Kahn
Sep 15, 2004·Biological Psychiatry·Neeltje E M van HarenRobin Murray
Feb 1, 2005·Journal of Autism and Developmental Disorders·Saskia J M C PalmenHerman van Engeland
Sep 17, 2005·Psychological Medicine·F V RijsdijkP C Sham
Feb 18, 2006·Journal of Clinical and Experimental Neuropsychology·Abraham ReichenbergMichael Davidson
Mar 7, 2007·Archives of General Psychiatry·Heleen B M BoosRené S Kahn
Apr 7, 2007·Human Brain Mapping·Jiska S PeperHilleke E Hulshoff Pol
May 4, 2007·The American Journal of Psychiatry·Mei-Hua HallPak Sham
Dec 7, 2007·Archives of General Psychiatry·Timothea ToulopoulouRobin Murray
Feb 28, 2008·Journal of Magnetic Resonance Imaging : JMRI·Clifford R JackMichael W Weiner
Mar 20, 2008·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·David B KeatorUNKNOWN BIRN-Coordinating
Oct 8, 2008·Development and Psychopathology·Katherine H KarlsgodtTyrone D Cannon
Feb 19, 2009·Schizophrenia Bulletin·S Hossein Fatemi, Timothy D Folsom
Jun 13, 2009·Human Genetics·Michael C O'DonovanMichael J Owen
Oct 8, 2009·Acta Psychiatrica Scandinavica·S Cohen-WoodsP McGuffin
Oct 13, 2009·Psychological Medicine·M GillA Corvin
Nov 11, 2009·International Review of Neurobiology·Nil Kaymaz, J van Os
Jan 6, 2010·The American Journal of Psychiatry·Abraham ReichenbergTerrie E Moffitt
Apr 7, 2010·Archives of General Psychiatry·Fruhling V RijsdijkEamon McCrory
Jun 12, 2010·Schizophrenia Bulletin·Ulrich EttingerMarco Picchioni
Nov 19, 2010·Human Brain Mapping·Hugo G SchnackHilleke E Hulshoff Pol

❮ Previous
Next ❯

Citations

Feb 16, 2013·Psychological Medicine·A F Terwisscha van ScheltingaR S Kahn
May 24, 2013·Brain : a Journal of Neurology·Marcel E MoranNitin Gogtay
Sep 11, 2013·Journal of Psychiatry & Neuroscience : JPN·Clifford CassidyRidha Joober
Dec 4, 2013·Schizophrenia Bulletin·Guusje CollinMartijn P van den Heuvel
Dec 31, 2015·Social Cognitive and Affective Neuroscience·Sanja BudisavljevicMarco Catani
Jul 21, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Monojit DebnathGanesan Venkatasubramanian
Oct 18, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·H W ThermenosL J Seidman
Jan 28, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·David C GlahnLaura Almasy
Jul 22, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Emma J RoseGary Donohoe
Apr 9, 2016·Schizophrenia Bulletin·Marc M BohlkenHilleke E Hulshoff Pol
Jul 24, 2013·Schizophrenia Research·René C W MandlHilleke E Hulshoff Pol
May 4, 2012·Psychiatry Research·Afke Terwisscha van ScheltingaRené Kahn
Jan 27, 2015·Schizophrenia Research·Patricia Alvarado-AlanisCamilo de la Fuente-Sandoval
Oct 9, 2012·Biological Psychiatry·Afke F Terwisscha van ScheltingaUNKNOWN Psychiatric Genome-wide Association Study Consortium
Oct 25, 2017·Brain Imaging and Behavior·Ashlee A MooreAnna R Docherty
Oct 12, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christian Stefan LegindBirte Yding Glenthøj
Sep 21, 2020·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Gisela SugranyesJosefina Castro-Fornieles
Apr 3, 2020·The American Journal of Psychiatry·René S Kahn

❮ Previous
Next ❯

Software Mentioned

Functional MRI of Automated Segmentation Tool ( FAST )
Mx Statistical Modeling

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Nature Genetics
Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium
The American Journal of Psychiatry
Irving I Gottesman, Todd D Gould
International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Caroline M ConnorSchahram Akbarian
Biological Psychiatry
Martijn P van den Heuvel, René S Kahn
© 2022 Meta ULC. All rights reserved