The Genetic and Environmental Factors of Primary Membranous Nephropathy: An Overview from China

Kidney Diseases
Xiao-Dan ZhangMinghui Zhao

Abstract

Primary membranous nephropathy (pMN) is the most common cause of nephrotic syndrome in adults. The discovery of the 2 autoantigens, M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A), has defined pMN as an autoimmune disease. A remarkable increase in the frequency of pMN in primary glomerular disease was witnessed in China. The genetic and environmental contributors to disease susceptibility have been investigated in these patients. We reviewed recent publications in genetic and environmental studies of pMN, focusing mainly on those undertaken in China. Following a genome-wide association study, the gene-gene interaction between the 2 most significant risk factors, PLA2R1 and DQA1, was validated in Chinese patients with MN. Fine mapping on human leukocyte antigen (HLA) locus found that DRB1*1501 and DRB1*0301 were risk alleles. Three amino acid residues on positions 13 and 71 of HLA-DRβ1 chain may confer the susceptibility to pMN by presenting T-cell epitopes on PLA2R. Another study found that DRB3*0202 was the most likely culprit allele for the signal at DRB1*0301. One environmental risk factor for pMN has been identified as the long-term exposure to high levels of PM2.5 in Chinese...Continue Reading

References

Mar 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M MeroniA Sessa
Nov 1, 1989·Tissue Antigens·R W VaughanK I Welsh
Jan 1, 1988·Nephron·A VangelistaV Bonomini
Jan 1, 1987·Nephron·K SatoS Yoshizawa
Jan 1, 1980·Kidney International·W G Couser, D J Salant
Apr 1, 1995·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·R W VaughanD G Williams
Dec 1, 1993·The Journal of Pediatrics·I ElshihabiA Brzowski
May 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P StrattaA Vercellone
Jan 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A GuellaP Ronco
May 4, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G L BradenM J Germain
Feb 22, 2001·QJM : Monthly Journal of the Association of Physicians·C W GraddenG M Bell
May 24, 2001·Yonsei Medical Journal·I J ChoiP K Kim
Jun 28, 2002·The New England Journal of Medicine·Hanna DebiecPierre M Ronco
Jan 31, 2004·Toxicology·Jean C PfauAndrij Holian
Jun 19, 2004·Inhalation Toxicology·Jared M BrownAndrij Holian
Aug 26, 2004·Kidney International·Pierre SimonNathalie Rioux
Oct 28, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ivan RychlíkVladimír Herout
Feb 3, 2007·The New England Journal of Medicine·Kristin A MillerJoel D Kaufman
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Sundararaman SwaminathanFernando C Fervenza
Aug 31, 2007·Drugs & Aging·Jeroen K J Deegens, Jack F M Wetzels
Apr 26, 2008·PLoS Genetics·Michelle M A FernandoJohn D Rioux
May 23, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cheng-Hsu ChenFuu-Jen Tsai
Aug 8, 2008·Clinical and Experimental Nephrology·Javed Iqbal KaziSyed Adeebul Hassan Rizvi
Mar 7, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jae Hyun ChangHo Yung Lee
Jun 3, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jennifer B HankoAisling E Courtney
Jul 3, 2009·The New England Journal of Medicine·Laurence H BeckDavid J Salant
Jul 28, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maria Goretti PolitoGianna Mastroianni Kirsztajn
Jul 29, 2010·Nephron. Clinical Practice·Keng-Thye WooKok-Seng Wong
Sep 2, 2010·Nephron. Clinical Practice·Sejoong KimUNKNOWN Progressive Renal Disease and Medical Informatics and Genomics Research (PREMIER) members
Feb 18, 2011·The New England Journal of Medicine·Horia C StanescuRobert Kleta
Mar 26, 2011·Clinical and Experimental Nephrology·Hitoshi SugiyamaUNKNOWN Committee for Standardization of Renal Pathological Diagnosis and Working Group for Renal Biopsy Database, Japanese Society
Apr 9, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Julia M HofstraDavid J Salant
May 14, 2011·Journal of the American Society of Nephrology : JASN·Weisong QinZhihong Liu
Jun 3, 2011·The New England Journal of Medicine·Hanna DebiecPierre Ronco
Jul 26, 2011·Journal of the American Society of Nephrology : JASN·Laurence H BeckDavid J Salant
Sep 29, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Agnes B Fogo

❮ Previous
Next ❯

Citations

Nov 20, 2018·Current Opinion in Nephrology and Hypertension·David J Salant
Nov 16, 2018·Expert Review of Clinical Immunology·Rolf Ak StahlElion Hoxha
May 3, 2019·Current Opinion in Nephrology and Hypertension·Agnieszka PozdzikFrancis Corazza
Oct 18, 2019·Annual Review of Pathology·Pierre Ronco, Hanna Debiec
Dec 8, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Luisa Safar-BoueriRivka Ayalon
Apr 30, 2021·Néphrologie & thérapeutique·Jens Lutz
Jun 8, 2021·Frontiers in Medicine·Shuang GaoMing-Hui Zhao
Aug 3, 2021·Journal of Immunology Research·Pingna ZhangWeijing Liu
Jun 5, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Wei-Bo LeSi-Wen Gong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Jean M FrancisDavid J Salant
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Guang-yu ZhouWen-long Zhang
Journal of the American Society of Nephrology : JASN
Zhao CuiMinghui Zhao
© 2022 Meta ULC. All rights reserved