The Genetic Architecture of Hearing Impairment in Mice: Evidence for Frequency-Specific Genetic Determinants

G3 : Genes - Genomes - Genetics
Amanda L CrowRick A Friedman

Abstract

Genome-wide association studies (GWAS) have been successfully applied in humans for the study of many complex phenotypes. However, identification of the genetic determinants of hearing in adults has been hampered, in part, by the relative inability to control for environmental factors that might affect hearing throughout the lifetime, as well as a large degree of phenotypic heterogeneity. These and other factors have limited the number of large-scale studies performed in humans that have identified candidate genes that contribute to the etiology of this complex trait. To address these limitations, we performed a GWAS analysis using a set of inbred mouse strains from the Hybrid Mouse Diversity Panel. Among 99 strains characterized, we observed approximately two-fold to five-fold variation in hearing at six different frequencies, which are differentiated biologically from each other by the location in the cochlea where each frequency is registered. Among all frequencies tested, we identified a total of nine significant loci, several of which contained promising candidate genes for follow-up study. Taken together, our results indicate the existence of both genes that affect global cochlear function, as well as anatomical- and freq...Continue Reading

References

Mar 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tim WiltshireColin F Fletcher
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kiran N Mahajan, Beverly S Mitchell
Oct 29, 2003·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Robin L Davis
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·B YalcinR Mott
Jul 13, 2006·Nature Genetics·William ValdarJonathan Flint
Dec 3, 2008·Human Molecular Genetics·Rick A FriedmanGuy Van Camp
Aug 12, 2009·Nature Methods·Hyuna YangGary A Churchill
May 14, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Qi Huang, Jianguo Tang
Feb 1, 2011·Hearing Research·Zoe F Mann, Matthew W Kelley
Sep 6, 2011·Nature Methods·Christoph LippertDavid Heckerman
Nov 8, 2011·Histochemistry and Cell Biology·Piotr MamczurDariusz Rakus
Aug 16, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Anatole GhazalpourRenée C LeBoeuf
Oct 10, 2012·Nature Reviews. Genetics·Jonathan Flint, Eleazar Eskin
Nov 6, 2012·American Journal of Human Genetics·Kemal O YarizMustafa Tekin
Jul 10, 2013·Annual Review of Genomics and Human Genetics·Richard Mott, Jonathan Flint
Dec 10, 2013·Nucleic Acids Research·Danielle WelterHelen Parkinson
Feb 27, 2014·Journal of the Association for Research in Otolaryngology : JARO·Jeffrey OhmenRick A Friedman
Jun 19, 2014·European Journal of Human Genetics : EJHG·Erik FransenRick A Friedman

❮ Previous
Next ❯

Citations

Oct 19, 2016·Journal of the Association for Research in Otolaryngology : JARO·Kevin K OhlemillerKenneth R Johnson
Apr 11, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sarah HiyariFlavia Q Pirih
Sep 27, 2018·Genesis : the Journal of Genetics and Development·Diana RigueurAmy E Merrill
May 4, 2018·Laryngoscope Investigative Otolaryngology·Nathan C Tu, Rick A Friedman
Aug 16, 2016·G3 : Genes - Genomes - Genetics·Joel LavinskyRick A Friedman
Aug 7, 2020·Journal of the Association for Research in Otolaryngology : JARO·Ely Cheikh BoussatyRick Adam Friedman
Jul 29, 2021·Human Genetics·Ely Cheikh BoussatyRoyce E Clifford

❮ Previous
Next ❯

Methods Mentioned

BETA
RNAseq

Software Mentioned

Ensembl genome browser
FaST
PolyPhen2
SIFT

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.