The genetic architecture of the association between eating behaviors and obesity: combining genetic twin modeling and polygenic risk scores

The American Journal of Clinical Nutrition
Guiomar MasipLeonie H Bogl

Abstract

Obesity susceptibility genes are highly expressed in the brain suggesting that they might exert their influence on body weight through eating-related behaviors. To examine whether the genetic susceptibility to obesity is mediated by eating behavior patterns. Participants were 3977 twins (33% monozygotic, 56% females), aged 31-37 y, from wave 5 of the FinnTwin16 study. They self-reported their height and weight, eating behaviors (15 items), diet quality, and self-measured their waist circumference (WC). For 1055 twins with genome-wide data, we constructed a polygenic risk score for BMI (PRSBMI) using almost 1 million single nucleotide polymorphisms. We used principal component analyses to identify eating behavior patterns, twin modeling to decompose correlations into genetic and environmental components, and structural equation modeling to test mediation models between the PRSBMI, eating behavior patterns, and obesity measures. We identified 4 moderately heritable (h2 = 36-48%) eating behavior patterns labeled "snacking," "infrequent and unhealthy eating," "avoidant eating," and "emotional and external eating." The highest phenotypic correlation with obesity measures was found for the snacking behavior pattern (r = 0.35 for BMI ...Continue Reading

References

Jan 1, 1982·Addictive Behaviors·J GormallyD Rardin
Oct 14, 1995·BMJ : British Medical Journal·B L Heitmann, L Lissner
Jan 8, 1998·American Journal of Epidemiology·J R HebertJ K Ockene
Dec 29, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J KarlssonM Sullivan
Nov 20, 2003·Twin Research : the Official Journal of the International Society for Twin Studies·Daniëlle PosthumaDorret I Boomsma
Sep 25, 2004·BMJ : British Medical Journal·Boyd Swinburn, Garry Egger
Mar 10, 2005·The American Journal of Clinical Nutrition·Sanna TholinJan Karlsson
Jan 26, 2007·European Journal of Clinical Nutrition·A Keski-RahkonenA Rissanen
Oct 2, 2007·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Birgit TeucherAlex J MacGregor
Aug 7, 2009·The International Journal of Eating Disorders·Ellen SchurDedra Buchwald
Sep 3, 2010·Nature·UNKNOWN International HapMap 3 ConsortiumJean E McEwen
Oct 1, 2011·American Journal of Human Biology : the Official Journal of the Human Biology Council·Aline JelenkovicKarri Silventoinen
May 31, 2012·Frontiers in Endocrinology·Cathy E ElksKen K Ong
Aug 29, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J MinY Wang
Feb 19, 2014·Journal of the American College of Nutrition·Kala SundararajanSisira Sarma
Feb 19, 2014·JAMA Pediatrics·Clare H LlewellynJane Wardle
Nov 26, 2014·European Journal of Public Health·Katja BorodulinPekka Puska
Jan 28, 2015·Psychometrika·Michael C NealeSteven M Boker
Feb 13, 2015·Nature·Dmitry ShunginKaren L Mohlke
Feb 13, 2015·Nature·Adam E LockeElizabeth K Speliotes
May 23, 2015·Human Molecular Genetics·Jennifer A NettletonPaul W Franks
May 26, 2015·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Hannah Cohen-ClineGlen E Duncan
Jun 19, 2015·The Journal of Nutrition·Teresa T FungFrank B Hu
Oct 3, 2015·American Journal of Human Genetics·Bjarni J VilhjálmssonNick Patterson
Apr 1, 2016·Obesity·Luz M León-MuñozFernando Rodríguez-Artalejo
Jun 1, 2016·Obesity Facts·Hélène HuvenneChristine Poitou
Aug 23, 2016·Nature Genetics·Shane McCarthyUNKNOWN Haplotype Reference Consortium
Aug 30, 2016·Nature Genetics·Sayantan DasChristian Fuchsberger
Oct 28, 2016·Nature Genetics·Po-Ru LohAlkes L Price
Oct 8, 2016·BMC Public Health·Katherine M Livingstone, Sarah A McNaughton
Aug 18, 2017·The American Journal of Clinical Nutrition·Blandine de Lauzon-GuillainKen K Ong
Nov 22, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H KonttinenA Haukkala
Apr 27, 2018·Current Diabetes Reports·Tatjana van Strien
Jul 10, 2018·The American Journal of Clinical Nutrition·Raphaëlle JacobLouis Pérusse
Jan 23, 2019·The European Journal of Neuroscience·Uku VainikAlain Dagher
Dec 5, 2019·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Milla KaidesojaJaakko Kaprio

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Citations

Aug 30, 2020·The American Journal of Clinical Nutrition·Patrícia Pelufo Silveira
Nov 5, 2021·The International Journal of Behavioral Nutrition and Physical Activity·Guiomar MasipUNKNOWN IDEFICS/I.Family Consortia

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Methods Mentioned

BETA
Genotyping
PCAs

Software Mentioned

Stata
R Project for Statistical Computing
Eagle
OpenMx
Minimac3
R

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