PMID: 10386270Jul 1, 1999Paper

The genetic basis for cardiac dysrhythmias and the long QT syndrome

The Journal of Cardiovascular Nursing
V M Vizgirda


Cardiac muscle excitation is the result of ion fluxes through cellular membrane channels. Any alterations in channel proteins that produce abnormal ionic fluxes will change the cardiac action potential and the pattern of electrical firing within the heart. The idiopathic long QT syndrome (LQTS) is an inherited cardiac pathology localized to mutated genes encoding for myocardial, voltage-activated sodium and potassium ion channels. The expression of abnormal sodium and potassium channels results in aberrant ionic fluxes that produce a prolonged ventricular repolarization. This prolonged time to repolarization is the electrophysiologic basis for prolongation of the QT interval. Individuals with LQTS are at significant risk for developing lethal ventricular dysrhythmias due to an abnormal pattern of cardiac excitation. Identification of a genetic basis for LQTS has had significant implications for genetic counseling, the development of effective antidysrhythmic drug therapies, and nursing interventions.


Jan 1, 1992·Circulation·A J Moss, J Robinson
Jan 27, 1992·Annals of the New York Academy of Sciences·A J Moss, J L Robinson
May 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R E ten EickH H Rasmussen
Apr 1, 1991·Circulation·C L Curry
Feb 1, 1985·American Heart Journal·D M Roden, R L Woosley
Sep 1, 1988·Progress in Cardiovascular Diseases·W M JackmanR Lazzara
Oct 1, 1993·Cardiovascular Research·E Coraboeuf, J Nargeot
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·J W Warmke, B Ganetzky
May 3, 1996·Science·M T Keating, M C Sanguinetti
Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·P B DavisM W Konstan
May 29, 1997·The New England Journal of Medicine·I SplawskiM T Keating
May 29, 1997·The New England Journal of Medicine·M J Ackerman, D E Clapham
May 1, 1997·Current Opinion in Cardiology·Q WangJ A Towbin
Nov 14, 1997·Nature Genetics·E Schulze-BahrH Funke
Mar 25, 1998·Mayo Clinic Proceedings·M J Ackerman
Aug 8, 1998·Trends in Cell Biology·J Gall, C Murphy
Feb 28, 2004·Trends in Cardiovascular Medicine·J BarhaninM Lazdunski
Feb 28, 2004·Trends in Cardiovascular Medicine·J Xu, M Li
Nov 1, 1994·Trends in Cardiovascular Medicine·D M Roden, M M Tamkun

❮ Previous
Next ❯

Related Concepts

Related Feeds


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.