The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length

Genetics
Daniel E CookErik C Andersen

Abstract

Telomeres are involved in the maintenance of chromosomes and the prevention of genome instability. Despite this central importance, significant variation in telomere length has been observed in a variety of organisms. The genetic determinants of telomere-length variation and their effects on organismal fitness are largely unexplored. Here, we describe natural variation in telomere length across the Caenorhabditis elegans species. We identify a large-effect variant that contributes to differences in telomere length. The variant alters the conserved oligonucleotide/oligosaccharide-binding fold of protection of telomeres 2 (POT-2), a homolog of a human telomere-capping shelterin complex subunit. Mutations within this domain likely reduce the ability of POT-2 to bind telomeric DNA, thereby increasing telomere length. We find that telomere-length variation does not correlate with offspring production or longevity in C. elegans wild isolates, suggesting that naturally long telomeres play a limited role in modifying fitness phenotypes in C. elegans.

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Related Concepts

Metazoa
DNA, Double-Stranded
Longevity
Variation (Genetics)
Telomere
Caenorhabditis elegans
Sequence Determinations, DNA
Caenorhabditis elegans Proteins
Telomer-Binding Protein, alpha-Subunit
Genome-Wide Association Study

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