The genetic basis of panic and phobic anxiety disorders

American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
J W SmollerJennifer Covino

Abstract

Panic disorder and phobic anxiety disorders are common disorders that are often chronic and disabling. Genetic epidemiologic studies have documented that these disorders are familial and moderately heritable. Linkage studies have implicated several chromosomal regions that may harbor susceptibility genes; however, candidate gene association studies have not established a role for any specific loci to date. Increasing evidence from family and genetic studies suggests that genes underlying these disorders overlap and transcend diagnostic boundaries. Heritable forms of anxious temperament, anxiety-related personality traits and neuroimaging assays of fear circuitry may represent intermediate phenotypes that predispose to panic and phobic disorders. The identification of specific susceptibility variants will likely require much larger sample sizes and the integration of insights from genetic analyses of animal models and intermediate phenotypes.

References

Apr 1, 1992·The American Journal of Psychiatry·J F RosenbaumJ Kagan
Apr 8, 1988·Science·J KaganN Snidman
May 1, 1988·Archives of General Psychiatry·J F RosenbaumN Snidman
Mar 1, 1986·Archives of General Psychiatry·R NoyesD R Chaudhry
Jul 1, 1995·Archives of General Psychiatry·A J FyerD F Klein
May 1, 1994·Archives of General Psychiatry·R B GoldsteinP J Wickramaratne
Apr 1, 1993·Archives of General Psychiatry·A J FyerD F Klein
Apr 12, 1996·Journal of Affective Disorders·V StarcevicD Pathak
Sep 1, 1995·Journal of Psychiatric Research·W MaierD Lichtermann
Mar 1, 1997·Archives of General Psychiatry·R B GoldsteinM M Weissman
Jan 20, 1998·The American Journal of Psychiatry·M B SteinJ R Walker
Apr 29, 1998·Journal of Anxiety Disorders·M A Mick, M J Telch
May 29, 1998·American Journal of Medical Genetics·Z WangR R Crowe
Jun 5, 1998·American Journal of Medical Genetics·J A KnowlesT C Gilliam
Jul 23, 1998·American Journal of Medical Genetics·C R CloningerP M Conneally
Dec 16, 1998·Journal of the American Academy of Child and Adolescent Psychiatry·C HaywardC B Taylor
Jul 8, 1999·Molecular Psychiatry·J L KennedyO Fourie
Aug 6, 1999·Journal of the American Academy of Child and Adolescent Psychiatry·C E SchwartzJ Kagan
Aug 24, 1999·The Journal of Clinical Psychiatry·P E GreenbergA J Fyer
Feb 25, 2000·American Journal of Medical Genetics·M M WeissmanJ A Knowles
Dec 1, 2000·The American Journal of Psychiatry·J F RosenbaumS V Faraone
Jan 4, 2001·Biological Psychiatry·H H Goldsmith, K S Lemery
Apr 17, 2001·American Journal of Medical Genetics·J W SmollerS A Slaugenhaupt
Aug 10, 2001·American Journal of Medical Genetics·J GelernterS Goodson
Sep 20, 2001·The Journal of Clinical Psychiatry·I K LyooJ S Kwon
Oct 2, 2001·The American Journal of Psychiatry·J M HettemaK S Kendler
Oct 3, 2002·The American Journal of Psychiatry·Jong-Min WooBum-Hee Yu
Jan 30, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ada H ZoharRichard P Ebstein
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Steven P HamiltonMyrna M Weissman
Apr 11, 2003·Neurogenetics·Deborah A FinnJohn C Crabbe
Jul 16, 2003·Archives of General Psychiatry·John M HettemaMats Fredrikson
Oct 9, 2003·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Thalia C EleyRobert Plomin

❮ Previous
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Citations

Dec 17, 2009·Molecular Psychiatry·E B Binder, C B Nemeroff
Nov 28, 2013·PloS One·Stefan WalterLaura D Kubzansky
Sep 14, 2010·Clinics in Laboratory Medicine·Elizabeth I MartinCharles B Nemeroff
Sep 1, 2009·The Psychiatric Clinics of North America·Elizabeth I MartinCharles B Nemeroff
Sep 1, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jordan W Smoller
Feb 9, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zaiyang LongUlrike Dydak
Dec 9, 2009·Biological Psychiatry·Sandeep GyawaliCharles E Glatt
Aug 8, 2012·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Verena LeutgebAnne Schienle
Jun 23, 2009·Neuroscience·S D Norrholm, K J Ressler
Dec 1, 2009·NeuroImage·Katharina Domschke, Udo Dannlowski
Jul 7, 2011·The American Journal of Orthopsychiatry·Cassandra DittmanKate Sofronoff
Jul 13, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Borwin BandelowPeter Riederer
Jan 16, 2010·Journal of Dental Research·J RayA G Broberg
Jun 23, 2015·International Journal of Environmental Research and Public Health·Rod Lambert
Jan 6, 2010·Molecular Psychiatry·E MaronJ Shlik
Oct 18, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jordan W Smoller
Dec 22, 2009·Psychiatric Genetics·Pernille KoefoedJens F Rehfeld
Sep 28, 2012·The Nurse Practitioner·Patricia G Oʼbrien, Loraine Fleming
Mar 4, 2019·Current Psychiatry Reports·Sandra M Meier, Jürgen Deckert
Oct 21, 2019·Child Psychiatry and Human Development·Alejandro de la Torre-LuqueXavier Bornas
Jul 6, 2010·Harvard Review of Psychiatry·Rafael C FreireAntonio E Nardi
Mar 18, 2021·Psychological Medicine·Andrew D Grotzinger
May 21, 2021·Clinical Psychological Science : a Journal of the Association for Psychological Science·Sylia WilsonMatt McGue
May 15, 2012·American Journal of Human Genetics·Carolyn B MervisLucy R Osborne

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