The genetic basis of postzygotic reproductive isolation between Drosophila santomea and D. yakuba due to hybrid male sterility

Genetics
Amanda J MoehringTrudy F C Mackay

Abstract

A major unresolved challenge of evolutionary biology is to determine the nature of the allelic variants of "speciation genes": those alleles whose interaction produces inviable or infertile interspecific hybrids but does not reduce fitness in pure species. Here we map quantitative trait loci (QTL) affecting fertility of male hybrids between D. yakuba and its recently discovered sibling species, D. santomea. We mapped three to four X chromosome QTL and two autosomal QTL with large effects on the reduced fertility of D. yakuba and D. santomea backcross males. We observed epistasis between the X-linked QTL and also between the X and autosomal QTL. The X chromosome had a disproportionately large effect on hybrid sterility in both reciprocal backcross hybrids. However, the genetics of hybrid sterility differ between D. yakuba and D. santomea backcross males, both in terms of the magnitude of main effects and in the epistatic interactions. The QTL affecting hybrid fertility did not colocalize with QTL affecting sexual isolation in this species pair, but did colocalize with QTL affecting the marked difference in pigmentation between D. yakuba and D. santomea. These results provide the basis for future high-resolution mapping and ultim...Continue Reading

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Citations

Aug 30, 2008·Molecular Biology and Evolution·Shamoni MaheshwariDaniel A Barbash
Feb 15, 2011·Genes & Genetic Systems·Keita SuwabeMasao Watanabe
Feb 12, 2014·PLoS Genetics·Tanmoy BhattacharyyaJiri Forejt
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Jul 2, 2009·Annals of the New York Academy of Sciences·Daniel Ortiz-BarrientosPatrik Nosil
Nov 7, 2009·Evolution; International Journal of Organic Evolution·Daniel R Matute, Jerry A Coyne
Sep 6, 2017·PLoS Genetics·David A Turissini, Daniel R Matute
Sep 3, 2011·Evolution; International Journal of Organic Evolution·Amanda J Moehring
Aug 23, 2018·Genetics·Ana LlopartJosep M Comeron
Mar 27, 2021·Biological Reviews of the Cambridge Philosophical Society·Tania Hernández-HernándezJohn J Wiens
Jul 1, 2021·Ecology and Evolution·Alexandre E PeluffoVirginie Courtier-Orgogozo
Jul 13, 2021·Frontiers in Genetics·Daven C Presgraves, Colin D Meiklejohn

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