The genetic diversity and geographical separation study of Oncomelania hupensis populations in mainland China using microsatellite loci

Parasites & Vectors
Wei GuanXiao-Nong Zhou

Abstract

Oncomelania hupensis is the unique intermediate host of Schistosoma japonicum, which plays a crucial role in the transmission of schistosomiasis. The endemic area of S. japonicum is strictly consistent with the geographical distribution of O. hupensis. A total of 24 populations of O. hupensis from four ecological landscapes were selected for analysis of genetic diversity by screening eight microsatellite DNA polymorphic loci. The number of alleles per locus ranged from 29 to 70 with an average of 45.625 and that of effective alleles were 18.5 to 45.8 with an average of 27.4. The observed (Ho) and expected (He) heterozygosities varied from 0.331 to 0.57 and from 0.888 to 0.974, respectively. The mean of polymorphism information content (PIC) for all populations was 0.940, appearing polymorphic for all loci. For the fixation index of F-Statistics, Fit and Fst were 54.95 and 37.62%, respectively. Variation of O. hupensis chiefly exists among individuals, accounting for 60.58% of the total variation determined by Analysis of Molecular Variation (AMOVA). Variation among individuals within populations, among populations within groups and among groups only accounted for 26.60, 8.04 and 4.78%, respectively. This distribution of variati...Continue Reading

References

Sep 13, 2003·Molecular Ecology·Adam G Jones, William R Ardren
Aug 5, 2004·Heredity·E E Dakin, J C Avise
Nov 29, 2005·Acta Tropica·Jürg UtzingerRobert Bergquist
Dec 8, 2006·Molecular Biology and Evolution·Marie-Pierre Chapuis, Arnaud Estoup
Oct 22, 2008·Lancet·Longde WangXiao-Nong Zhou
Jan 9, 2009·The New England Journal of Medicine·Long-De WangXiao-Nong Zhou

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Citations

Oct 19, 2017·PLoS Neglected Tropical Diseases·Gengping ZhuA Townsend Peterson
Mar 1, 2019·Tropical Medicine and Infectious Disease·Catherine A GordonDarren J Gray
Jul 22, 2019·Microbiology Spectrum·Ronald E Blanton

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Methods Mentioned

BETA
PCR

Software Mentioned

Arlequin
UPGMA
DataTrans
Popgene
Geneious
Excel
Genepop
TreeView

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