The Genetic Epidemiology of Treated Major Depression in Sweden

The American Journal of Psychiatry
Kenneth S KendlerKristina Sundquist

Abstract

The authors examined the heritability of treated major depression in a twin and full/half-sibling design, to describe key genetic epidemiological features of major depression and to determine which clinical indices of genetic liability optimally predict risk of depression in relatives. The authors examined all treated cases of major depression in Sweden recorded in inpatient, specialist, and primary care registries and, using OpenMx, estimated the etiologic role of genetic and environmental factors from monozygotic and dizygotic twin pairs and full and half siblings reared together and apart (total N=1,718,863 pairs). Eight indices of genetic risk were examined in 875,010 proband-relative pairs. The heritability of major depression in men and women was estimated at 0.41 (95% CI=0.21, 0.49) and 0.49 (95% CI=0.31, 0.56), respectively, in the twin design and 0.36 (95% CI=0.31, 0.38) and 0.51 (95% CI=0.51, 0.53), respectively, in the independent full/half-sibling design. The best estimate of the correlation in genetic effects across sexes was 0.89 (95% CI=0.87, 0.91). The results also showed evidence of modest shared environmental effects (0.02-0.05). Seven of the eight indices predicted risk for major depression in relatives, with...Continue Reading

Citations

Jan 8, 2019·Advances in Nutrition·Sorayya Kheirouri, Mohammad Alizadeh
Jul 4, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julian MacoveanuKamilla Woznica Miskowiak
Oct 4, 2020·Acta Psychiatrica Scandinavica·M K Wium-AndersenM Osler
Nov 10, 2020·Journal of Youth and Adolescence·Erin E DunningLauren B Alloy
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Oct 18, 2020·Journal of the American Academy of Child and Adolescent Psychiatry·Subina UpadhyayaLiisa Lehtonen
Mar 9, 2021·Psychological Medicine·K M KendallY Lu
Mar 12, 2021·Human Molecular Genetics·Victoria L MartucciMelinda C Aldrich
Jul 23, 2021·Molecular Psychiatry·Bradley S JermyEvangelos Vassos
Jul 15, 2021·The American Journal of Psychiatry·Alexis C EdwardsKristina Sundquist
Oct 1, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amy E MilesYuliya S Nikolova
Jan 9, 2022·Molecular Psychiatry·Thuy-Dung NguyenYi Lu
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Software Mentioned

OpenMx
SAS

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