The genetic factors of bilaterian evolution.

ELife
Peter HegerThomas Wiehe

Abstract

The Cambrian explosion was a unique animal radiation ~540 million years ago that produced the full range of body plans across bilaterians. The genetic mechanisms underlying these events are unknown, leaving a fundamental question in evolutionary biology unanswered. Using large-scale comparative genomics and advanced orthology evaluation techniques, we identified 157 bilaterian-specific genes. They include the entire Nodal pathway, a key regulator of mesoderm development and left-right axis specification; components for nervous system development, including a suite of G-protein-coupled receptors that control physiology and behaviour, the Robo-Slit midline repulsion system, and the neurotrophin signalling system; a high number of zinc finger transcription factors; and novel factors that previously escaped attention. Contradicting the current view, our study reveals that genes with bilaterian origin are robustly associated with key features in extant bilaterians, suggesting a causal relationship.

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References

Oct 1, 1991·Journal of Neurobiology·W J MoodyM Villaz
Dec 1, 1990·Genes & Development·A M MichelsonT Maniatis
Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·K M Brown, J R Shaver
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y Kim, M Nirenberg
Sep 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M Carlberg, M Anctil
Sep 15, 1996·Developmental Biology·R P Harvey
Jun 1, 1997·Molecular Phylogenetics and Evolution·S Q IrvineM Q Martindale
Oct 24, 1997·Science·R L TatusovD J Lipman
Jan 27, 1999·Bioinformatics·S R Eddy
May 29, 2000·Trends in Genetics : TIG·P RiceA Bleasby
Aug 10, 2000·The Journal of Experimental Zoology·M J Kourakis, M Q Martindale
Feb 13, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K JaglaM Frasch
Apr 28, 2001·Evolution & Development·J R Finnerty, M Q Martindale
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
Dec 26, 2001·Current Opinion in Structural Biology·B Kobe, A V Kajava
Dec 26, 2001·Molecular Biology and Evolution·P LopezH Philippe
Feb 28, 2002·Genome Biology·Fyodor A KondrashovEugene V Koonin
Apr 5, 2002·Genome Research·W James Kent
Sep 11, 2002·Molecular Phylogenetics and Evolution·Guillaume BalavoineAndré Adoutte
Dec 25, 2002·Current Biology : CB·Yu Chen, Alexander F Schier
Jan 23, 2003·Genome Biology·Pavel TomancakGerald M Rubin
Apr 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Graham N LukePeter W H Holland
Sep 4, 2003·Genome Research·Gavin C Conant, Andreas Wagner
Sep 4, 2003·Genome Research·Li LiDavid S Roos
Nov 26, 2003·Current Opinion in Genetics & Development·Nina M Brooke, Peter W H Holland
Mar 20, 2004·Developmental Cell·Véronique DubocThierry Lepage
May 26, 2004·Physiology & Behavior·Kent C Berridge
Oct 7, 2004·European Journal of Pharmacology·Satoshi SuoHubert H M Van Tol
Nov 9, 2004·Bioinformatics·Johannes Söding
Jan 22, 2005·Nucleic Acids Research·Kazutaka KatohTakashi Miyata
Feb 11, 2005·Molecular Biology and Evolution·Hervé PhilippeHenner Brinkmann
Mar 8, 2005·Development·Clare Hudson, Hitoyoshi Yasuo
Mar 23, 2005·The Journal of Experimental Biology·Erik C JohnsonPaul H Taghert

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Citations

Feb 25, 2021·Proceedings. Biological Sciences·Scott D EvansDouglas H Erwin
Mar 5, 2021·IScience·Paschalis NatsidisMaximilian J Telford
Jun 6, 2021·Nature Reviews. Gastroenterology & Hepatology·Akimasa HayashiChristine A Iacobuzio-Donahue
Nov 9, 2021·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Punit GandhiAdriana T Dawes

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Software Mentioned

HMM
CEGMA ( Core Eukaryotic Genes Mapping Approach )
R
FigTree
BLAST
MySQL
Emboss
MAFFT
custom
PfamScan

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