PMID: 45606Jan 1, 1979

The genetic fine structure of the complex locus aro3 involved in early aromatic amino acid biosynthesis in Schizosaccharomyces pombe

Molecular & General Genetics : MGG
A Strauss

Abstract

The complex locus aro3 of Schizosaccharomyces pombe was subjected to genetical fine structure analysis. By comparing the complementation map and the meiotic recombination map, the aro3 locus could be subdivided into the five adjacent subregions A, B, C, D and E. Out of 115 aro3 alleles, 26 nonsense alleles and 30 missense alleles could be identified by the criteria of nonsense suppressor sensitivity and leakiness, respectively. Most alleles with a pleiotropic complementation pattern are of the nonsense type. We conclude from the polarity of the complementation patterns characterising the nonsense alleles that the translation direction proceeds from subregion. A to subregion E. Antipolar effects in complementation are more frequent than in the analogous system of the arom gene cluster of Neurospora crassa.

References

Jan 1, 1992·Current Genetics·G G Lennon, H Lehrach
Jan 1, 1984·Molecular & General Genetics : MGG·N Nakanishi, M Yamamoto
Mar 11, 1986·Nucleic Acids Research·I G CharlesA R Hawkins
Jan 1, 1981·Zeitschrift für allgemeine Mikrobiologie·R Bode, D Birnbaum
Jan 1, 1983·Zeitschrift für allgemeine Mikrobiologie·R Bode, G Kunze
Jan 1, 1983·Zeitschrift für allgemeine Mikrobiologie·R Bode

Citations

Mar 21, 1977·Biochemical and Biophysical Research Communications·F H Gaertner, K W Cole
Sep 15, 1973·Experientia·M E Schweingruber, R Dietrich
Jul 1, 1969·Journal of Bacteriology·M B Berlyn, N H Giles
Aug 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·B ShafferG R Fink
Jan 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·M E Case, N H Giles
Jan 1, 1963·Endeavour·A WISEMAN

Related Concepts

Neurospora crassa
Recombination, Genetic
Amino Acid Biosynthesis
Meiotic Recombination
PARPBP gene
Genes, Fungal
Aromatics
M Phase, Meiotic
Gene Clusters
Locus

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.