PMID: 45606Jan 1, 1979

The genetic fine structure of the complex locus aro3 involved in early aromatic amino acid biosynthesis in Schizosaccharomyces pombe

Molecular & General Genetics : MGG
A Strauss


The complex locus aro3 of Schizosaccharomyces pombe was subjected to genetical fine structure analysis. By comparing the complementation map and the meiotic recombination map, the aro3 locus could be subdivided into the five adjacent subregions A, B, C, D and E. Out of 115 aro3 alleles, 26 nonsense alleles and 30 missense alleles could be identified by the criteria of nonsense suppressor sensitivity and leakiness, respectively. Most alleles with a pleiotropic complementation pattern are of the nonsense type. We conclude from the polarity of the complementation patterns characterising the nonsense alleles that the translation direction proceeds from subregion. A to subregion E. Antipolar effects in complementation are more frequent than in the analogous system of the arom gene cluster of Neurospora crassa.


Jan 1, 1992·Current Genetics·G G Lennon, H Lehrach
Jan 1, 1984·Molecular & General Genetics : MGG·N Nakanishi, M Yamamoto
Mar 11, 1986·Nucleic Acids Research·I G CharlesA R Hawkins
Jan 1, 1981·Zeitschrift für allgemeine Mikrobiologie·R Bode, D Birnbaum
Jan 1, 1983·Zeitschrift für allgemeine Mikrobiologie·R Bode, G Kunze
Jan 1, 1983·Zeitschrift für allgemeine Mikrobiologie·R Bode


Mar 21, 1977·Biochemical and Biophysical Research Communications·F H Gaertner, K W Cole
Sep 15, 1973·Experientia·M E Schweingruber, R Dietrich
Jul 1, 1969·Journal of Bacteriology·M B Berlyn, N H Giles
Aug 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·B ShafferG R Fink
Jan 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·M E Case, N H Giles
Jan 1, 1963·Endeavour·A WISEMAN

Related Concepts

Neurospora crassa
Recombination, Genetic
Amino Acid Biosynthesis
Meiotic Recombination
Genes, Fungal
M Phase, Meiotic
Gene Clusters

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