The genetic polymorphism and expression profiles of NLRP3 inflammasome in patients with chronic myeloid leukemia

Human Immunology
Amin ZhangDaoxin Ma

Abstract

NLRP3 inflammasome has been recently reported as an important risk factor in the development of cancer. But the relationship between polymorphisms of NLRP3 inflammasome related genes and chronic myeloid leukemia (CML) is rarely reported. Therefore, the aim of the present study was to investigate the association of five genetic polymorphisms (NLRP3, IL-1β, IL-18, CARD8 and NF-κB) in 267 CML patients and 344 healthy controls. We found that the AT genotype of CARD8 (rs2043211) was significantly higher compared to TT genotype in high and intermediate risk CML patients. IL-1β (rs16944) polymorphism in early molecular response at 6 months was marginally different, with more GG and less AA genotype in BCR-ABLIS >1% group. IL-18 (rs1946518) polymorphism was significantly different with more GG genotype in BCR-ABLIS >1% group at 6 months. We also demonstrated that WBC count of newly diagnosed patients carrying AG genotype was significantly higher than that of GG or AA genotype of IL-1β (rs16944). The onset age of patients carrying ins/ins genotype of NF-κB (rs28362491) was significantly older than that of ins/del and del/del genotype. Moreover, IL-1β or NLRP3 mRNA expression was decreased and IL-18 mRNA expression was increased signific...Continue Reading

Citations

Apr 30, 2020·Clinical and Experimental Immunology·Q LiuD Ma
Nov 19, 2018·Molecular Cancer·Maryam MoossaviAmirhossein Sahebkar
Aug 1, 2020·Frontiers in Immunology·Shaima'a Hamarsheh, Robert Zeiser
Oct 11, 2019·The Journal of Biological Chemistry·Su-Ho ParkTae Sung Kim
Jul 9, 2020·Cancers·Cédric Rébé, François Ghiringhelli
Feb 3, 2021·International Journal of Molecular Sciences·Laura UrwanischJutta Horejs-Hoeck
Mar 13, 2021·Nature Immunology·Bhesh Raj Sharma, Thirumala-Devi Kanneganti
Jun 23, 2019·Life Sciences·Chaelin LeeInmoo Rhee
Jul 3, 2021·Signal Transduction and Targeted Therapy·Yangxin LiYao-Hua Song

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