PMID: 17613220Jul 7, 2007Paper

The genetic predisposition to and histogenesis of neurofibromas and neurofibrosarcoma in neurofibromatosis type 1

Neurosurgical Focus
V Riccardi

Abstract

The author addresses the issue of neurofibroma classification and implications for treatment. He emphasizes the importance of understanding that not all neurofibromas are the same and that the key differences between the types of neurofibromas involve which portions of the nerve sheath contribute to the distinctive behavior of the different types of lesions. Endoneurial neurofibromas derive from cellular elements ordinarily restricted to the endoneurium. Perineurial neurofibromas arise within individual fascicles of a nerve and are largely confined thereby, precluding a breach of the epineurium. Epineurial neurofibromas are contained only by the epineurium, and ultimately that portion of the nerve sheath is breached by these lesions. Whether the perineurium is present or breached becomes the key element for exploiting this approach to neurofibroma origins, behaviors, and treatment, surgical and medical. With respect to surgical treatment, perineurial neurofibromas will have clean planes of dissection about the involved nerve. In contrast, endoneurial and epineurial neurofibromas infiltrate adjacent tissues, leading to surgical challenges. With respect to pharmaceutical approaches, the integrity of the perineurium is likely to p...Continue Reading

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Citations

May 8, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jean-Paul SteibCharles Philippe
Feb 9, 2011·Clinical Oral Investigations·Eeva-Mari JouhilahtiJuha Peltonen
Jun 19, 2008·Neuro-oncology·Victor-F MautnerJan M Friedman
Jan 4, 2013·Stem Cells Translational Medicine·Elizabeth A SalisburyElizabeth A Olmsted-Davis
Feb 26, 2013·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Evelyn OkunoghaeBarbara Gray
Aug 20, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Vincent Michael Riccardi
Apr 23, 2015·American Journal of Medical Genetics. Part a·Kimberly JettVictor F Mautner
May 15, 2015·American Journal of Medical Genetics. Part a·Vincent M Riccardi
Apr 5, 2011·The American Journal of Pathology·Eeva-Mari JouhilahtiJuha Peltonen
Dec 22, 2017·Orphanet Journal of Rare Diseases·Rafaela E Rozza-de-MenezesKarin S Cunha
Nov 30, 2018·Journal of Neurosurgery. Spine·Mueez WaqarCalvin Soh
Dec 23, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Kimberly Jett, Jan M Friedman
Jun 23, 2018·Head and Neck Pathology·Faraj M AlotaibyIndraneel Bhattacharyya
Aug 23, 2019·Acta neurochirurgica·Ignazio G VetranoVittoria Nazzi
Oct 27, 2018·Frontiers in Cellular Neuroscience·Jo Anne StrattonJeff Biernaskie
Jul 8, 2021·Neurology·Chetan BettegowdaUNKNOWN REiNS International Collaboration

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