PMID: 17613220Jul 7, 2007Paper

The genetic predisposition to and histogenesis of neurofibromas and neurofibrosarcoma in neurofibromatosis type 1

Neurosurgical Focus
V Riccardi


The author addresses the issue of neurofibroma classification and implications for treatment. He emphasizes the importance of understanding that not all neurofibromas are the same and that the key differences between the types of neurofibromas involve which portions of the nerve sheath contribute to the distinctive behavior of the different types of lesions. Endoneurial neurofibromas derive from cellular elements ordinarily restricted to the endoneurium. Perineurial neurofibromas arise within individual fascicles of a nerve and are largely confined thereby, precluding a breach of the epineurium. Epineurial neurofibromas are contained only by the epineurium, and ultimately that portion of the nerve sheath is breached by these lesions. Whether the perineurium is present or breached becomes the key element for exploiting this approach to neurofibroma origins, behaviors, and treatment, surgical and medical. With respect to surgical treatment, perineurial neurofibromas will have clean planes of dissection about the involved nerve. In contrast, endoneurial and epineurial neurofibromas infiltrate adjacent tissues, leading to surgical challenges. With respect to pharmaceutical approaches, the integrity of the perineurium is likely to p...Continue Reading


Apr 1, 1985·The British Journal of Dermatology·J F NorrisM J Hand
Jan 1, 1969·Journal of Clinical Pathology·G Manley, U Williams
Nov 1, 1965·Brain : a Journal of Neurology·S Sunderland
Jan 1, 1980·Journal of Cancer Research and Clinical Oncology·S A Vinores, J R Perez-Polo
Jul 1, 1994·Nature Genetics·T JacksR A Weinberg
Jan 1, 1993·American Journal of Medical Genetics·J M FriedmanC Greene
Jan 1, 1993·Annual Review of Neuroscience·D ViskochilR Cawthon
Oct 3, 2003·Genes & Development·Mark H G VerheijenGreg Lemke
Jun 1, 1952·The Anatomical Record·S SUNDERLAND, K C BRADLEY
Aug 27, 2005·The New England Journal of Medicine·Nader SanaiMitchel S Berger
Jun 1, 1945·Brain : a Journal of Neurology·S SUNDERLAND

❮ Previous
Next ❯


May 8, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jean-Paul SteibCharles Philippe
Feb 9, 2011·Clinical Oral Investigations·Eeva-Mari JouhilahtiJuha Peltonen
Jun 19, 2008·Neuro-oncology·Victor-F MautnerJan M Friedman
Jan 4, 2013·Stem Cells Translational Medicine·Elizabeth A SalisburyElizabeth A Olmsted-Davis
Feb 26, 2013·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Evelyn OkunoghaeBarbara Gray
Aug 20, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Vincent Michael Riccardi
Apr 23, 2015·American Journal of Medical Genetics. Part a·Kimberly JettVictor F Mautner
May 15, 2015·American Journal of Medical Genetics. Part a·Vincent M Riccardi
Apr 5, 2011·The American Journal of Pathology·Eeva-Mari JouhilahtiJuha Peltonen
Dec 22, 2017·Orphanet Journal of Rare Diseases·Rafaela E Rozza-de-MenezesKarin S Cunha
Nov 30, 2018·Journal of Neurosurgery. Spine·Mueez WaqarCalvin Soh
Dec 23, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Kimberly Jett, Jan M Friedman
Jun 23, 2018·Head and Neck Pathology·Faraj M AlotaibyIndraneel Bhattacharyya
Aug 23, 2019·Acta neurochirurgica·Ignazio G VetranoVittoria Nazzi
Oct 27, 2018·Frontiers in Cellular Neuroscience·Jo Anne StrattonJeff Biernaskie
Jul 8, 2021·Neurology·Chetan BettegowdaUNKNOWN REiNS International Collaboration

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

JAMA : the Journal of the American Medical Association
Ludwine MessiaenE Legius
Journal of the American Academy of Dermatology
Kevin P BoydAmy Theos
Journal of Medical Genetics
Eric PasmantPierre Wolkenstein
© 2021 Meta ULC. All rights reserved