The genetic reconstruction of BCG as a new immunotherapeutic tool

Trends in Biotechnology
Michael A O'Donnell

Abstract

The bacillus of Calmette and Guérin (BCG), long appreciated for its role as a live vaccine for the prevention of tuberculosis, is undergoing a rebirth as a recombinant delivery vehicle for foreign antigens and bioactive proteins. Recombinant BCG causes long-lived specific humoral and cellular immunity and may ultimately prove to be a powerful and cost-effective new weapon against both infectious pathogens and certain cancers.

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Citations

May 21, 1999·Lancet·A B AlexandroffK James
Feb 27, 2001·Biomolecular Engineering·B Drabner, C A Guzmán
Jan 10, 2004·The Journal of Urology·Kent G KrejciEugene D Kwon
Sep 24, 1999·The Journal of Urology·Y LuoM A O'Donnell
May 6, 2009·Urologic Oncology·Michael A O'Donnell

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