PMID: 3747727Sep 1, 1986Paper

The genetically epilepsy-prone rat: an overview of seizure-prone characteristics and responsiveness to anticonvulsant drugs

Life Sciences
C E ReigelP C Jobe

Abstract

The Genetically Epilepsy-Prone Rat (GEPR) is rapidly gaining support as a model of epilepsy. In addition to a marked sensitivity to both sound-induced and hyperthermic seizures, GEPRs exhibit unusual sensitivity to a number of seizure-provoking modalities, including various forms of electrical and chemical stimulation. The existence of a moderate seizure colony (GEPR-3) and a severe seizure colony (GEPR-9) allows pathophysiological studies of seizure susceptibility and severity. The consistency of seizures within each colony allows for comparisons in seizure naive GEPRs and seizure experienced GEPRs. The consistent seizure responses of the GEPR are also ideal for the testing of anticonvulsant drugs. Further, the relative potencies of anticonvulsant drugs between the two colonies of GEPRs predict the clinical efficacies of traditional antiepileptic drugs and may be able to predict novel anticonvulsants.

Citations

Jun 1, 1987·Metabolic Brain Disease·C L Faingold
Feb 1, 1995·Italian Journal of Neurological Sciences·P C JobeJ W Dailey
Aug 1, 1989·Molecular and Chemical Neuropathology·H E Laird
Jan 1, 1991·Life Sciences·R R RowlandD D Savage
Apr 1, 1992·Pharmacology, Biochemistry, and Behavior·C R Craig, B K Colasanti
Sep 1, 1996·Pharmacology, Biochemistry, and Behavior·G De SarroA de Sarro
Jul 1, 1989·Brain Research. Brain Research Reviews·R S Fisher
Jan 1, 1988·General Pharmacology·C L Faingold
Jan 1, 1994·Brain Research Bulletin·A SaijaG De Sarro
Jan 1, 1994·Brain Research Bulletin·P C JobeJ W Dailey
Mar 1, 1988·Epilepsy Research·S A Mills, D D Savage
Oct 1, 1992·Epilepsy Research·M Pierson, S L Liebmann
Aug 7, 2013·Epilepsy Research·Melissa M Carballosa-GonzalezDolores E López

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