The genetics and molecular pathogenesis of systemic lupus erythematosus (SLE) in populations of different ancestry

Gene
George N GoulielmosTimothy B Niewold

Abstract

Systemic lupus erythematosus (SLE; OMIM 152700) is a highly heterogeneous disorder, characterized by differences in autoantibody profile, serum cytokines, and a multi-system involvement commonly affecting the skin, renal, musculoskeletal, and hematopoetic systems clinical manifestations involving. Disease features range from mild manifestations, such as rash or arthritis, to life-threatening end-organ manifestations, such as glomerulonephritis or thrombosis, and it is difficult to predict which manifestations will affect a given patient. SLE is caused by interactions between susceptibility genes and environmental factors resulting in an irreversible loss of immunologic self-tolerance. Incidence is highest in women during the reproductive years; however, people of all ages, genders, and ancestral backgrounds are susceptible. A striking 9:1 female to male differential appears in incidence, which remains largely unexplained. However, people of both sexes and all ages and ethnic backgrounds are susceptible. Distinct differences regarding the pathogenesis of SLE between patients of different ancestral backgrounds have been observed so far, including differences in specific clinical manifestations, disease-susceptibility genetic vari...Continue Reading

Citations

Oct 2, 2019·Current Opinion in Allergy and Clinical Immunology·Antonella Cianferoni, Isabella Annesi-Maesano
Sep 19, 2019·Immunological Medicine·Takeshi Tsubata
Jan 23, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Theresa L Wampler MuskardinTimothy B Niewold
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