The genetics of antibody response to paratuberculosis in dairy cattle

Journal of Dairy Science
T PritchardE Wall

Abstract

Genetic parameters were estimated for antibody response to paratuberculosis (Mycobacterium avium ssp. paratuberculosis) using milk ELISA test results, collected and analyzed by National Milk Records, from Holstein Friesian cows on UK dairy farms in their first 3 lactations. Milk ELISA test results were obtained from 2007 to 2012 and combined with milk recording data and pedigree information. The reduced data set edited for the purposes of genetic parameter estimation consisted of 148,054 milk ELISA records from 64,645 lactations in 40,142 cows of 908 sires, recorded in 641 herds. Milk ELISA test results were loge-transformed and univariate analysis of 3 alternative animal models and equivalent sire models were considered. The most appropriate model included additive genetic and permanent environmental random effects, whereas maternal effects were significant according to likelihood ratio test and Akaike's information criterion but not for Bayesian information criterion. Heritability and repeatability estimates were 0.06 and 0.37, respectively, for the chosen animal model and its equivalent sire model. A subset of the data including herds with greater than 10% positive tests gave a slightly higher heritability of 0.08. Favorable...Continue Reading

References

Jul 1, 1996·The Veterinary Clinics of North America. Food Animal Practice·R W Sweeney
Mar 21, 2000·American Journal of Human Genetics·M AbneyC Ober
Dec 19, 2000·Veterinary Microbiology·G BenedictusJ W Hesselink
Aug 10, 2001·Journal of Long-term Effects of Medical Implants·S L BrownC M Parmentier
Jan 27, 2004·Journal of Dairy Science·E WallM P Coffey
Apr 12, 2006·Journal of Dairy Science·M G GondaB W Kirkpatrick
Oct 12, 2007·The Veterinary Journal·Richard J Whittington, Peter A Windsor
Sep 27, 2008·Preventive Veterinary Medicine·Søren Saxmose Nielsen, Nils Toft
Mar 27, 2010·Journal of Dairy Science·S A AttallaB J Heins
May 11, 2010·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Solis NortonCord Heuer
Mar 1, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·John M Adaska, Robert H Whitlock
Oct 4, 2012·Animal : an International Journal of Animal Bioscience·T PritchardE Wall

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