PMID: 9526905Apr 4, 1998Paper

The genetics of asthma

Current Opinion in Pulmonary Medicine
H S KimC K Oh

Abstract

The genetic approach to asthma has revealed a few candidate genes. Among them, special attention is given to the association between chromosome 5q and various cytokines and also to chromosome 11q and the IgE receptor. A mutation in chromosome 5 enhances interleukin-4 activity, which increases IgE synthesis by plasma cells. Polymorphism in the beta chain of the high-affinity IgE receptor (FC epsilonRI-beta) is considered to play a key role in the pathogenesis of asthma. Increased IgE, caused by both mutations, is responsible for inflammatory allergic reactions. A possible link between genetics and asthma has been suggested, although some studies could not confirm an association. Further study of the candidate genes may allow at-risk individuals to be tested and new treatments to be developed.

Citations

May 17, 2000·Current Opinion in Pulmonary Medicine·M A Brown, M Halonen
Dec 22, 1999·The American Journal of Cardiology·S Z RoseroM L Andrews
Jan 6, 1999·Cell·S C GarmanT S Jardetzky
Jan 22, 2004·Experimental Biology and Medicine·Seong H ChoChad K Oh

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