Aug 31, 2015

The genetics of Bene Israel from India reveals both substantial Jewish and Indian ancestry

BioRxiv : the Preprint Server for Biology
Yedael Y WaldmanAlon Keinan

Abstract

The Bene Israel Jewish community from West India is a unique population whose history before the 18th century remains largely unknown. Bene Israel members consider themselves as descendants of Jews, yet the identity of these ancestors and their arrival time to India are unknown, with speculations on arrival time varying between the 8th century BCE and the 6th century CE. Here, we characterize the genetic history of Bene Israel by collecting and genotyping 18 Bene Israel individuals. Combining with 438 individuals from 32 other Jewish and Indian populations, and additional individuals from worldwide populations, we conducted comprehensive genome-wide analyses based on FST, PCA, ADMIXTURE, identity-by-descent sharing, admixture LD decay, haplotype sharing and allele sharing autocorrelation decay, as well as contrasted patterns between the X chromosome and the autosomes. Bene Israel individuals resemble local Indian populations, while at the same time constituting a clearly separated and unique population in India. They share genetic ancestry with other Jewish populations to an extent not observed for any other Indian population. Putting the results together point to Bene Israel being an admixed population with both Jewish and Ind...Continue Reading

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Mentioned in this Paper

Genome-Wide Association Study
Patterns
Genetic Analysis
Genetic Screening Method
Dysequilibrium Syndrome
X Chromosome
Contrast Used
MALL gene
Local
Analysis

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