PMID: 7547224Oct 1, 1995Paper

The genetics of breast and ovarian cancer

British Journal of Cancer
D Ford, D F Easton

Abstract

A number of genes are known to be involved in inherited susceptibility to breast and/or ovarian cancer. In the context of high-risk families the most important genes are BRCA1 on chromosome 17q, which is associated with a high penetrance of both breast and ovarian cancer, and BRCA2 on chromosome 13q, which causes a high risk of breast cancer but a lower risk of ovarian cancer. Other high-risk cancer genes that confer increased risks of breast or ovarian cancer in addition to other cancers include the hereditary non-polyposis colorectal cancer genes and the TP53 gene, which causes breast cancer as part of the Li-Fraumeni syndrome. The predisposing mutations in these genes are relatively rare in the population. More common genes which are associated with an increased, but lower, risk of breast cancer are the ataxiatelangiectasia gene and the HRAS1 gene. This paper reviews recent progress in mapping and cloning of these susceptibility genes, and provides estimates of the cancer risks associated with each gene and the frequency of predisposing mutations.

Citations

Oct 27, 1997·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·A Luz
May 20, 1999·Radiation Oncology Investigations·T A BuchholzM D McNeese
Sep 2, 1999·British Journal of Cancer·D G BebbB W Glickman
Mar 4, 2000·Plastic and Reconstructive Surgery·J S SolomonJ D Friedman
Feb 15, 2000·The British Journal of Surgery·G H Sakorafas, A G Tsiotou
Jul 19, 2001·Journal of the National Cancer Institute·M J StoutjesdijkJ O Barentsz
Nov 2, 2011·Journal of the National Cancer Institute. Monographs·Giuseppe Curigliano, Aron Goldhirsch
Aug 12, 2016·Journal of Adolescent and Young Adult Oncology·Sara GiordanoMary Ellen Pavone
Jul 13, 2016·Journal of Genetic Counseling·Alejandra Hurtado-de-MendozaVanessa B Sheppard
Apr 30, 2019·Frontiers in Endocrinology·Kyung-A SonDooSeok Choi
Sep 25, 1997·International Journal of Cancer. Journal International Du Cancer·E NegriF Parazzini
Aug 30, 2000·Oncogene·S JinQ Zhan
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A. KoulÅ. Borg Å
Apr 21, 1999·Clinical Endocrinology·T RimanS Nilsson
Jul 30, 2003·Expert Opinion on Therapeutic Targets·Suzanne M Russo, Roger Ove
Nov 25, 2004·Technology in Cancer Research & Treatment·Dag PavicEtta D Pisano
Nov 30, 2005·Virchows Archiv : an International Journal of Pathology·Yoon-La ChoiGeunghwan Ahn
May 26, 2017·Cancer Nursing·Anita CarusoPaola Gremigni
Jan 5, 2002·The Journal of Biological Chemistry·Wenhong FanQimin Zhan
Jul 11, 2003·The British Journal of Surgery·R S PrichardN J O'Higgins
Jan 12, 2000·Cancer·A BerchuckP A Futreal
Jun 7, 2000·Obstetrical & Gynecological Survey·S J Fasouliotis, J G Schenker
Jul 7, 2000·Seminars in Surgical Oncology·W H GotliebE Friedman
Apr 8, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Reshma JagsiSarah T Hawley
May 27, 2014·American Society of Clinical Oncology Educational Book·Melinda Telli
Sep 2, 2015·Journal of Genetic Counseling·Rebekah J HamiltonDawn T Bounds
Dec 16, 1998·British Journal of Obstetrics and Gynaecology·R BellT Sheldon
Jun 16, 1999·Breast Cancer Research and Treatment·X Yang, M E Lippman
Aug 4, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Zhihong ZhangJinsong Liu
Feb 25, 1999·The Australian and New Zealand Journal of Surgery·I C BennettB T Teh
Dec 22, 1999·Genetic Epidemiology·A B Baffoe-BonnieH Tulinius
Nov 27, 1998·Annals of Surgical Oncology·A MogilnerS T Brower
Nov 17, 2011·Molecular Carcinogenesis·Shaik Mohammad NaushadVijay Kumar Kutala

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxia telangiectasia

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

© 2021 Meta ULC. All rights reserved