The genetics of obsessive-compulsive disorder and Tourette syndrome: an epidemiological and pathway-based approach for gene discovery

Journal of the American Academy of Child and Adolescent Psychiatry
Marco A Grados

Abstract

To provide a contemporary perspective on genetic discovery methods applied to obsessive-compulsive disorder (OCD) and Tourette syndrome (TS). A review of research trends in genetics research in OCD and TS is conducted, with emphasis on novel approaches. Genome-wide association studies (GWAS) are now in progress in OCD and TS and will provide a platform for future discovery of common gene variants. Optimally, newer next-generation genome sequencing methods can also be used to detect larger effect genes (rare gene variants), taking advantage of pedigrees. Studies of gene networks or sets rather than individual genes will be required to elucidate biological etiology, as neural systems appear to act redundantly. Newer phenotyping strategies, such as symptom-based subtypes, cross-disorder latent class types, and intermediate phenotypes (endophenotypes) will need to be developed and tested to better align clinical and physiological measures with genetic architecture. Although genetics research has made significant advances based on computational strength and bioinformatics advances, newer approaches to phenotyping and judicious study of gene etiological networks will be needed to uncover the genetic etiology of OCD and TS.

References

Jul 1, 1992·Archives of General Psychiatry·J L RapoportM Kriete
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·M KarayiorgouJ A Gogos
Sep 19, 1997·Archives of General Psychiatry·D R RosenbergJ A Sweeney
Mar 10, 2001·Nature·J D McPhersonUNKNOWN International Human Genome Mapping Consortium
Oct 17, 2001·The International Journal of Neuropsychopharmacology·B CamarenaH Nicolini
Feb 2, 2002·The American Journal of Psychiatry·John P Alsobrook, David L Pauls
Jul 13, 2002·American Journal of Medical Genetics·Gregory L HannaEdwin H Cook
Oct 3, 2002·The American Journal of Psychiatry·Daniela Di BellaLaura Bellodi
Dec 24, 2002·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Bruno MilletMarie-Odile Krebs
Feb 1, 2003·Clinical Psychology Review·Scott Greisberg, Dean McKay
Mar 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Sîan M J HemmingsDan J Stein
Jul 5, 2003·Journal of Psychosomatic Research·David L Pauls
Jun 1, 2004·The American Journal of Psychiatry·Sanjaya SaxenaLewis R Baxter
Jun 9, 2004·Archives of General Psychiatry·David Mataix-ColsMary L Phillips
Jul 24, 2004·American Journal of Human Genetics·Virginia L WillourGerald Nestadt
Dec 22, 2004·Molecular Psychiatry·E C MiguelD L Pauls
Jan 7, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Gregory L HannaBrenda W Gillespie
May 14, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Maria Conceição do Rosario-CamposDavid L Pauls
Oct 15, 2005·Science·Jesse F AbelsonMatthew W State
Oct 22, 2005·Biological Psychiatry·James J HudziakDorret I Boomsma
Jan 31, 2006·Journal of Affective Disorders·Damiaan DenysHerman G M Westenberg
Apr 4, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Gregor HaslerDennis L Murphy
Apr 28, 2006·American Journal of Human Genetics·Xian-Zhang HuDavid Goldman
May 6, 2006·Neuron·Chang-Hyuk KwonLuis F Parada
Jul 5, 2006·Archives of General Psychiatry·Paul Daniel ArnoldJames L Kennedy
Oct 24, 2006·Current Opinion in Genetics & Development·David R Bentley

❮ Previous
Next ❯

Citations

May 1, 2012·European Child & Adolescent Psychiatry·Eli R LebowitzJames F Leckman
Mar 23, 2012·Genes, Brain, and Behavior·P PaschouM Grigoriou
Mar 22, 2012·Journal of Psychiatry & Neuroscience : JPN·Pino AlonsoJosé M Menchón
May 10, 2011·American Journal of Clinical Dermatology·Khalid Al Hawsawi, Elena Pope
Mar 4, 2014·Journal of Medical Case Reports·Issam S Al-JanabiAllal Ouhtit
Oct 24, 2013·Expert Opinion on Drug Discovery·Marco A GradosDiandra Fortune
Dec 3, 2013·Journal of the American Academy of Child and Adolescent Psychiatry·Tanya K MurphyUNKNOWN American Academy of Child and Adolescent Psychiatry (AACAP) Committee on Quality Issues (CQI)
May 25, 2011·Current Opinion in Neurobiology·Jonathan T Ting, Guoping Feng
Apr 30, 2011·Neuroscience and Biobehavioral Reviews·Zsofia NemodaMaria Sasvari-Szekely
Nov 10, 2011·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Anjené M Addington, Judith L Rapoport
Jul 21, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·James J Hudziak, Stephen V Faraone
Aug 28, 2012·Neuron·Genevieve KonopkaDaniel H Geschwind
Jan 22, 2013·Neuroscience and Biobehavioral Reviews·Peristera Paschou
Jul 11, 2016·Psychiatry Research·Fabiana Barzotti KohlrauschLeonardo Franklin Fontenelle
Mar 14, 2012·Nature Reviews. Neurology·Hao DengJoseph Jankovic
Jun 13, 2019·Brain Imaging and Behavior·Vanessa M SinopoliPaul D Arnold
Jan 19, 2021·European Child & Adolescent Psychiatry·Judith BuseUNKNOWN EMTICS collaborative group
May 8, 2021·Neuropsychiatric Disease and Treatment·Natalia Szejko, Kirsten R Müller-Vahl

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.