The Genetics of Physical Activity

Current Cardiology Reports
Xiaochen LinSimin Liu


Physical activity (PA) is a well-established modifiable lifestyle determinant for multiple cardio-metabolic outcomes. While many psychosocial and environmental correlates of PA have been identified, current understanding of the genetic architecture that contributes to PA is still very limited, especially when compared to other phenotypes such as obesity and diabetes. This review systematically and comprehensively assesses available evidence from animal experiments, family studies, population-based candidate gene analyses, and genome-wide association studies (GWAS) studying the genetics of physical activity patterns. It discusses the scientific evolution in the field of PA genetics, including the recognition of increased sample sizes, the shift from early family-based approaches to association-based design, and the rapidly advancement of enabling genotyping and sequencing technologies. In addition, this review points to the gaps in the current knowledge base, including the general lack of GWAS and whole-genome sequence analyses particularly understudied populations, and the need for large-scale collaborative effort in both observational and experimental settings. In this review, we also call for research utilizing systems biolog...Continue Reading


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Jul 7, 2018·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Sara PereiraJosé Maia
Mar 15, 2018·Medicine and Science in Sports and Exercise·Xiaochen LinSimin Liu
Mar 26, 2019·Clinical Obesity·Dennis J KerriganGwen L Alexander
Jul 4, 2019·Journal of Applied Physiology·Louis P Watanabe, Nicole C Riddle
Jun 27, 2020·European Journal of Preventive Cardiology·Maxime BoidinDick Thijssen
Jul 8, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J R SpeakmanD B Allison
Jan 24, 2021·The International Journal of Behavioral Nutrition and Physical Activity·Lene AasdahlEivind Schjelderup Skarpsno
Feb 22, 2021·European Journal of Preventive Cardiology·Maxime BoidinDick Thijssen
Dec 24, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Theresia M SchnurrTorben Hansen
Mar 6, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Elisa Marin-CoutureAngelo Tremblay

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