The genetics of polycystic ovary syndrome

Best Practice & Research. Clinical Obstetrics & Gynaecology
Paula Amato, Joe Leigh Simpson

Abstract

Polycystic ovary syndrome (PCOS) is a heterogeneous disorder. There is evidence for a genetic component in PCOS based on familial clustering of cases. The majority of the evidence supports an autosomal dominant form of inheritance. Steroidogenesis has been shown to be upregulated in PCOS theca cells, suggesting that the genetic abnormality in PCOS affects signal transduction pathways controlling the expression of a family of genes. Although a number of candidate genes have been proposed, the putative PCOS gene(s) has yet to be identified. Linkage and association studies implicate a region near the insulin receptor gene at chr 19p13.3. New genetic approaches, such as microarray technology, hold promise for elucidation of the pathophysiology underlying PCOS.

References

Jan 1, 1989·Gynecologic and Obstetric Investigation·O LundeS Høglo
Dec 1, 1988·Clinical Endocrinology·W M HagueH S Jacobs
Jan 1, 1984·Postgraduate Medical Journal·C Hutton, F Clark
May 1, 1996·The Journal of Clinical Endocrinology and Metabolism·J A TalbotR N Clayton
Nov 1, 1996·The Journal of Clinical Endocrinology and Metabolism·N GharaniS Franks
Aug 15, 1998·Journal of Pediatric and Adolescent Gynecology·S F WitchelE P Hoffman
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·R S LegroA Dunaif
Jan 27, 1999·The Journal of Clinical Endocrinology and Metabolism·A GovindR N Clayton
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·M UrbanekA Dunaif
Aug 12, 1999·The Journal of Clinical Endocrinology and Metabolism·L IbáñezN Potau
Feb 13, 2001·Fertility and Sterility·M D Kahsar-MillerR Azziz
Dec 12, 2001·The Journal of Clinical Endocrinology and Metabolism·V L NelsonJ M McAllister
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·David A EhrmannNancy J Cox
Jun 7, 2002·The Journal of Clinical Endocrinology and Metabolism·Lema HaddadMark I McCarthy
Jun 25, 2002·Human Reproduction Update·Robert A Wild
Jun 28, 2002·Diabetes Care·Jana VrbíkováLuboslav Stárka
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Olavi UkkolaClaude Bouchard
Sep 6, 2002·The Journal of Clinical Endocrinology and Metabolism·David A EhrmannGraeme I Bell
Sep 7, 2002·Fertility and Sterility·Richard S Legro, Jerome F Strauss
Dec 28, 2002·Diabetes·Margrit UrbanekRichard S Legro
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Lourdes IbáñezDavid B Dunger
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Alejandro GonzalezAgustín Ruiz
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Francesco OrioGaetano Lombardi
Jan 9, 2004·Fertility and Sterility·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group

❮ Previous
Next ❯

Citations

Apr 24, 2009·Journal of Assisted Reproduction and Genetics·Tugba UnsalAdnan Menevse
Jul 3, 2013·Hormones & Cancer·Lisa K PhilpTanya K Day
Mar 18, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nicholas HatzirodosRaymond J Rodgers
Jun 8, 2011·Reproductive Biology and Endocrinology : RB&E·Xinghua XuZi-Jiang Chen
Sep 3, 2009·Theoretical Biology & Medical Modelling·Zeti-Azura Mohamed-Hussein, Sarahani Harun
Sep 22, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C Diana JordanLynn Y Sakai
Feb 24, 2007·Journal of Pediatric Endocrinology & Metabolism : JPEM·Elizabeth E LittlejohnRobert Rosenfield
Mar 24, 2009·Obstetrics and Gynecology·Joseph S Sanfilippo, Eduardo Lara-Torre
Jul 30, 2014·Eating and Weight Disorders : EWD·Laura PalaCarlo Maria Rotella
May 1, 2007·Women's Health·Ephia Yasmin, Adam H Balen
Jan 18, 2007·Der Internist·D HeutlingH Lehnert
Feb 25, 2014·Fertility and Sterility·Wenjuan ZhangZi-Jiang Chen
Jun 26, 2010·Gynécologie, obstétrique & fertilité·G RobinC Decanter
Nov 1, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·X SongZi-Jiang Chen
Aug 30, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·José Luis MárquezLuis A Salazar
Sep 7, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·Roy Homburg
Jul 20, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·D Siassakos, P Wardle
Jun 23, 2015·The Journal of Obstetrics and Gynaecology Research·Kitirat TechatraisakWanna Thongnoppakhun
Jun 3, 2015·Reproductive Biology and Endocrinology : RB&E·Huiqin YuanMo Shen
Jul 5, 2006·Neurourology and Urodynamics·Simon Podnar, Matija Barbic
Nov 16, 2006·The Journal of Clinical Endocrinology and Metabolism·Beata BanaszewskaAntoni J Duleba
Oct 18, 2007·The Journal of Clinical Endocrinology and Metabolism·Mark O GoodarziRicardo Azziz
Jan 5, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Joseph F MaherBryan D Cowan
Apr 9, 2009·The Journal of Clinical Endocrinology and Metabolism·Esther A M KuijperDorret I Boomsma
Nov 16, 2006·American Journal of Physiology. Endocrinology and Metabolism·Caren VollmertUNKNOWN KORA group
Apr 4, 2009·Seminars in Cutaneous Medicine and Surgery·Francisco M Camacho-Martínez
May 21, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Andrea D Coviello
Aug 16, 2013·Obstetrical & Gynecological Survey·Jaya MehtaDaniel Dumesic
Mar 7, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Xiaomeng WangLin Xu
Feb 8, 2007·Molecular Human Reproduction·M R JonesB G A Stuckey
Dec 5, 2018·Reproductive Biology and Endocrinology : RB&E·Zhengling LiuJingjing Fu
Oct 31, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Youn Kyung ChungYoung Min Choi
Jan 24, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Paramita SahaRakesh K Tyagi
Apr 8, 2021·Reproductive Sciences·Matheus Credendio EirasCristiana Libardi Miranda Furtado

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

© 2021 Meta ULC. All rights reserved