The genetics of the myelodysplastic syndromes: classical cytogenetics and recent molecular insights

Hematology
Sindhu Cherian, Adam Bagg

Abstract

Myelodysplastic syndromes (MDS) are a complex group of clonal hematopoietic disorders with an attendant diverse array of associated genetic changes. Conventional cytogenetics plays a prominent and well-established role in determining the contemporary diagnosis and prognosis of these disorders. More recently, molecular approaches have been useful in further characterizing this group of diseases, albeit in a largely experimental context, with the detection of changes at the single gene level including mutations, amplification and epigenetic phenomena. Nevertheless, we remain largely ignorant of the genetic underpinnings of MDS. Here we briefly review the established role of cytogenetics in MDS, and emphasize recent advances in unraveling the genetics of MDS, with a view towards how such findings might facilitate our ability to understand, diagnose and treat these disorders in a more rational manner.

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Citations

Mar 14, 2007·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Jin-Yeong Han, Karl S Theil
Nov 5, 2013·Critical Reviews in Oncology/hematology·Heidrun KarlicMichael Pfeilstöcker
Nov 26, 2008·Cancer Genetics and Cytogenetics·Claudia HaferlachAlan List
Oct 9, 2009·Internal Medicine Journal·Y MaG Lin
Jan 8, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ulrike BacherTorsten Haferlach

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