The Genome of a Thermo Tolerant, Pathogenic Albino Aspergillus fumigatus

Frontiers in Microbiology
Brian CougerRolf A Prade

Abstract

Biotechnologists are interested in thermo tolerant fungi to manufacture enzymes active and stable at high temperatures, because they provide improved catalytic efficiency, strengthen enzyme substrate interactions, accelerate substrate enzyme conversion rates, enhance mass transfer, lower substrate viscosity, lessen contamination risk and offer the potential for enzyme recycling. Members of the genus Aspergillus live a wide variety of lifestyles, some embrace GRAS status routinely employed in food processing while others such as Aspergillus fumigatus are human pathogens. A. fumigatus produces melanins, pyomelanin protects the fungus against reactive oxygen species and DHN melanin produced by the pksP gene cluster confers the gray-greenish color. pksP mutants are attenuated in virulence. Here we report on the genomic DNA sequence of a thermo tolerant albino Aspergillus isolated from rain forest composted floors. Unexpectedly, the nucleotide sequence was 95.7% identical to the reported by Aspergillus fumigatus Af293. Genome size and predicted gene models were also highly similar, however differences in DNA content and conservation were observed. The albino strain, classified as Aspergillus fumigatus var. niveus, had 160 gene model...Continue Reading

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Datasets Mentioned

BETA
PRJNA237468
PRJNA18733

Methods Mentioned

BETA
FCS
PCR

Software Mentioned

GlimmerHMM
HMMER
PASA
BLAST
PFAM
EVidenceModeler
EVM
MEGA
AFUMN
BLAST +

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