The Genome of a Tortoise Herpesvirus (Testudinid Herpesvirus 3) Has a Novel Structure and Contains a Large Region That Is Not Required for Replication In Vitro or Virulence In Vivo

Journal of Virology
Frédéric GandarA Vanderplasschen

Abstract

Testudinid herpesvirus 3 (TeHV-3) is the causative agent of a lethal disease affecting several tortoise species. The threat that this virus poses to endangered animals is focusing efforts on characterizing its properties, in order to enable the development of prophylactic methods. We have sequenced the genomes of the two most studied TeHV-3 strains (1976 and 4295). TeHV-3 strain 1976 has a novel genome structure and is most closely related to a turtle herpesvirus, thus supporting its classification into genus Scutavirus, subfamily Alphaherpesvirinae, family Herpesviridae. The sequence of strain 1976 also revealed viral counterparts of cellular interleukin-10 and semaphorin, which have not been described previously in members of subfamily Alphaherpesvirinae. TeHV-3 strain 4295 is a mixture of three forms (m1, m2, and M), in which, in comparison to strain 1976, the genomes exhibit large, partially overlapping deletions of 12.5 to 22.4 kb. Viral subclones representing these forms were isolated by limiting dilution assays, and each replicated in cell culture comparably to strain 1976. With the goal of testing the potential of the three forms as attenuated vaccine candidates, strain 4295 was inoculated intranasally into Hermann's to...Continue Reading

References

Jul 1, 1992·Virology·E A TelfordA J Davison
Apr 1, 1992·Immunology Today·A G ZapataM Torroba
Jul 20, 1992·Journal of Molecular Biology·M Levitt
Nov 14, 1997·Zentralblatt für Veterinärmedizin. Reihe A·N Pusterla, U Braun
May 29, 1998·The Journal of General Virology·E A TelfordA J Davison
Jul 27, 2001·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·R E MarschangE F Kaleta
Dec 26, 2001·Bioinformatics·H Shimodaira, M Hasegawa
Apr 6, 2002·Bioinformatics·Heiko A SchmidtArndt von Haeseler
May 11, 2002·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·J HervásJ C Gómez-Villamandos
Jul 1, 1963·Journal of Molecular Biology·G N RAMACHANDRANV SASISEKHARAN
Jan 13, 2004·Veterinary Pathology·F C OriggiE R Jacobson
Mar 23, 2004·Nucleic Acids Research·Robert C Edgar
May 11, 2006·PLoS Biology·Alexei J DrummondAndrew Rambaut
Jul 22, 2006·Veterinary Microbiology·Rachel E MarschangBernhard N Roth
Aug 26, 2006·The Veterinary Clinics of North America. Exotic Animal Practice·Craig J-G Hunt
Mar 10, 2007·The Veterinary Journal·Frank PasmansNikola Pantchev
Mar 20, 2008·Genome Research·Daniel R Zerbino, Ewan Birney
Mar 28, 2008·Molecular Biology and Evolution·Si Quang Le, Olivier Gascuel
Apr 18, 2008·Briefings in Bioinformatics·Sudhir KumarKoichiro Tamura
Jun 10, 2008·Journal of Theoretical Biology·Tanja Gernhard
Jan 21, 2009·Journal of Virology·B CostesA Vanderplasschen
Feb 11, 2009·Journal of Wildlife Diseases·A MartelF Pasmans
Mar 3, 2009·Genome Research·Jared T SimpsonInanç Birol
Jan 19, 2010·Bioinformatics·Heng Li, Richard Durbin
Mar 30, 2010·Veterinary Microbiology·Andrew J Davison
Jul 6, 2010·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Elizabeth J BickneseJames F X Wellehan
Nov 24, 2011·Proceedings of the National Academy of Sciences of the United States of America·Derek GathererAndrew J Davison
Mar 1, 2012·Molecular Biology and Evolution·Alexei J DrummondAndrew Rambaut
Mar 27, 2012·Briefings in Bioinformatics·Iain MilneDavid Marshall
Aug 17, 2012·Journal of Virology·Céline LétéLaurent Gillet
Oct 12, 2012·PloS One·Mathias AckermannJo-Ann C Leong

❮ Previous
Next ❯

Citations

May 24, 2011·The Veterinary Clinics of North America. Exotic Animal Practice·Tracy Bennett
Jul 30, 2017·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Ekaterina KolesnikRachel E Marschang
May 24, 2016·PloS One·Konstantinos V PapageorgiouAndrew J Davison
Apr 30, 2017·Virus Genes·Günther SchönrichMartin J Raftery
Jan 27, 2021·Journal of Comparative Pathology·Tom HellebuyckRachel E Marschang
Sep 1, 2019·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Dana M LindemannRebecca L Smith
Jan 23, 2021·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·John M WinterMatthew C Allender
Apr 25, 2021·The Veterinary Clinics of North America. Exotic Animal Practice·Rachel E MarschangMichael Pees
May 25, 2021·Frontiers in Veterinary Science·God'spower Richard OkohEllen Ariel
Jun 17, 2021·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Rachel E MarschangKacper Stanicki
Nov 2, 2021·Frontiers in Veterinary Science·Christoph LeineweberRachel E Marschang
Dec 4, 2021·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·Lisa SchülerRachel E Marschang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.