The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation [corrected].

PloS One
Dongbo LiuXingyao Xiong

Abstract

Ganoderma lucidum (Reishi or Ling Zhi) is one of the most famous Traditional Chinese Medicines and has been widely used in the treatment of various human diseases in Asia countries. It is also a fungus with strong wood degradation ability with potential in bioenergy production. However, genes, pathways and mechanisms of these functions are still unknown. The genome of G. lucidum was sequenced and assembled into a 39.9 megabases (Mb) draft genome, which encoded 12,080 protein-coding genes and ∼83% of them were similar to public sequences. We performed comprehensive annotation for G. lucidum genes and made comparisons with genes in other fungi genomes. Genes in the biosynthesis of the main G. lucidum active ingredients, ganoderic acids (GAs), were characterized. Among the GAs synthases, we identified a fusion gene, the N and C terminal of which are homologous to two different enzymes. Moreover, the fusion gene was only found in basidiomycetes. As a white rot fungus with wood degradation ability, abundant carbohydrate-active enzymes and ligninolytic enzymes were identified in the G. lucidum genome and were compared with other fungi. The genome sequence and well annotation of G. lucidum will provide new insights in function analyse...Continue Reading

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Aug 30, 2014·Natural Product Reports·Maureen B QuinClaudia Schmidt-Dannert
Oct 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Mei-Yeh Jade LuWen-Hsiung Li
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Methods Mentioned

BETA
glycosylation

Software Mentioned

Genewise
- MCL
tRNAscan
rRNAmmer
RepeatScout
Swiss
TrEMBL
MUSCLE
SE
Rfam

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