The Genome of the Fungal Pathogen Verticillium dahliae Reveals Extensive Bacterial to Fungal Gene Transfer

Genome Biology and Evolution
Xiaoqian Shi-KunneMichael F Seidl

Abstract

Horizontal gene transfer (HGT) involves the transmission of genetic material between distinct evolutionary lineages and can be an important source of biological innovation. Reports of interkingdom HGT to eukaryotic microbial pathogens have accumulated over recent years. Verticillium dahliae is a notorious plant pathogen that causes vascular wilt disease on hundreds of plant species, resulting in high economic losses every year. Previously, the effector gene Ave1 and a glucosyltransferase-encoding gene were identified as virulence factor-encoding genes that were proposed to be horizontally acquired from a plant and a bacterial donor, respectively. However, to what extent HGT contributed to the overall genome composition of V. dahliae remained elusive. Here, we systematically searched for evidence of interkingdom HGT events in the genome of V. dahliae and provide evidence for extensive horizontal gene acquisition from bacterial origin.

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Citations

Jun 18, 2020·Plants·Nuria Montes-Osuna, Jesús Mercado-Blanco
Jul 28, 2020·International Journal of Molecular Sciences·Jorge A Ramírez-TejeroFrancisco Luque
Nov 18, 2020·Phytopathology·Pauline HessenauerRichard C Hamelin
Apr 24, 2021·Annual Review of Phytopathology·Jie-Yin ChenKrishna V Subbarao

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Datasets Mentioned

BETA
SRP149060
PRJNA473305

Methods Mentioned

BETA
RNA-Seq
Illumina sequencing

Software Mentioned

RAxML
Interproscan
Gblocks
TBlastN
SignalP
R
edgeR
Python script
BLAST
TargetP

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