The genome sequence of the rumen methanogen Methanobrevibacter ruminantium reveals new possibilities for controlling ruminant methane emissions.

PloS One
S C LeahyG T Attwood

Abstract

Methane (CH(4)) is a potent greenhouse gas (GHG), having a global warming potential 21 times that of carbon dioxide (CO(2)). Methane emissions from agriculture represent around 40% of the emissions produced by human-related activities, the single largest source being enteric fermentation, mainly in ruminant livestock. Technologies to reduce these emissions are lacking. Ruminant methane is formed by the action of methanogenic archaea typified by Methanobrevibacter ruminantium, which is present in ruminants fed a wide variety of diets worldwide. To gain more insight into the lifestyle of a rumen methanogen, and to identify genes and proteins that can be targeted to reduce methane production, we have sequenced the 2.93 Mb genome of M. ruminantium M1, the first rumen methanogen genome to be completed. The M1 genome was sequenced, annotated and subjected to comparative genomic and metabolic pathway analyses. Conserved and methanogen-specific gene sets suitable as targets for vaccine development or chemogenomic-based inhibition of rumen methanogens were identified. The feasibility of using a synthetic peptide-directed vaccinology approach to target epitopes of methanogen surface proteins was demonstrated. A prophage genome was descri...Continue Reading

References

Aug 1, 1978·Archives of Microbiology·O Kandler, H König
Feb 1, 1975·Canadian Journal of Microbiology·J G Zeikus, V G Bowen
Jan 1, 1992·Canadian Journal of Microbiology·K F JarrellM L Kalmokoff
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Mar 1, 1993·Nature Genetics·W Gish, D J States
May 1, 1996·Molecular Biology and Evolution·J R Lobry
Jun 6, 1998·Cellular and Molecular Life Sciences : CMLS·O Kandler, H König
Jan 27, 1999·Bioinformatics·S R Eddy
Nov 11, 1999·Nucleic Acids Research·A L DelcherS L Salzberg
Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Dec 11, 1999·Nucleic Acids Research·R L TatusovE V Koonin
Feb 15, 2000·Research in Microbiology·L J JensenD W Ussery
May 29, 2000·Trends in Genetics : TIG·P RiceA Bleasby
Dec 20, 2000·Bioinformatics·K RutherfordB Barrell
Jul 27, 2001·Current Opinion in Chemical Biology·P R CaronM A Murcko
Dec 26, 2001·Nucleic Acids Research·Alex BatemanErik L L Sonnhammer
Feb 12, 2002·Bioinformatics·James K BonfieldRodger Staden
Dec 27, 2002·The Journal of General and Applied Microbiology·Mitsunori TokuraKazunari Ushida
Jan 10, 2003·Nucleic Acids Research·Daniel H HaftOwen White
Jan 4, 1965·Biochemical and Biophysical Research Communications·M J ALLISON
Sep 26, 2003·Omics : a Journal of Integrative Biology·Eric Altermann, Todd R Klaenhammer
Jan 22, 2004·Bioinformatics·Nancie ReymondJean-Michel Fayard
Jun 30, 2004·Journal of Molecular Biology·Jannick Dyrløv BendtsenSøren Brunak
Jul 5, 2005·Journal of Bacteriology·Jos BoekhorstRoland J Siezen
May 13, 2006·Molecular Microbiology·Amit P Bhavsar, Eric D Brown
Jul 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Susanne M D GoldbergJ Craig Venter
Feb 6, 2007·Genome Biology·Sheila Podell, Terry Gaasterland
Apr 21, 2007·Nature Protocols·Olof EmanuelssonHenrik Nielsen
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Buck S SamuelJeffrey I Gordon
Oct 2, 2007·Current Opinion in Microbiology·Juan A HermosoPedro García
Nov 28, 2007·Nucleic Acids Research·Robert D FinnAlex Bateman

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Citations

Nov 11, 2014·Annual Review of Animal Biosciences·Carl J Yeoman, Bryan A White
Jun 14, 2014·Proceedings of the National Academy of Sciences of the United States of America·Hao WangKaarina Sivonen
Feb 10, 2011·Standards in Genomic Sciences·Iain AndersonNikos C Kyrpides
Sep 29, 2011·The Journal of Biological Chemistry·Duncan G G McMillanGregory M Cook
Sep 21, 2013·International Journal of Environmental Research and Public Health·Christy E Manyi-LohMichael Simon
Nov 12, 2013·Applied and Environmental Microbiology·Ciara A CarberryChristopher J Creevey
Oct 4, 2012·Animal : an International Journal of Animal Bioscience·D P MorgaviG T Attwood
Jun 14, 2013·Animal : an International Journal of Animal Bioscience·D N WedlockB M Buddle
Jun 14, 2013·Animal : an International Journal of Animal Bioscience·S C LeahyG T Attwood
Aug 31, 2013·Standards in Genomic Sciences·S C LeahyG T Attwood
Jul 12, 2012·Applied Microbiology and Biotechnology·Sunil Kumar SirohiAnil Kumar Puniya
Nov 20, 2013·Applied Microbiology and Biotechnology·Sanjay KumarAnil Kumar Puniya
Jan 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·David BerryMichael Wagner
Apr 24, 2013·Journal of Environmental Management·X L ZhangR Y Surampalli
May 1, 2012·Journal of Biotechnology·Vímac Nolla-ArdèvolHalina E Tegetmeyer
Mar 30, 2010·The Veterinary Journal·Bryce M BuddleD Neil Wedlock
Nov 26, 2015·Trends in Biotechnology·Julian HillKourosh Kalantar-Zadeh
Oct 19, 2011·Environmental Microbiology·Margret E Berg MillerBryan A White
Oct 21, 2015·Archaea : an International Microbiological Journal·Linley R SchofieldRon S Ronimus
Apr 20, 2016·Frontiers in Microbiology·Dragana GagicJasna Rakonjac
Apr 9, 2016·Genome Announcements·William J KellySinead C Leahy
Aug 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Alexander N HristovStephane Duval
Sep 29, 2015·Standards in Genomic Sciences·Suzanne C LambieEric Altermann
Aug 19, 2015·Frontiers in Microbiology·Benoit St-PierreAndré-Denis G Wright
Nov 12, 2014·Annual Review of Animal Biosciences·Stuart E Denman, Christopher S McSweeney
Jan 18, 2013·Archaea : an International Microbiological Journal·Christoph WredeMichael Hoppert
May 18, 2016·BMC Genomics·Ambarish BiswasChris M Brown
Jun 13, 2015·PLoS Pathogens·Mor N Lurie-Weinberger, Uri Gophna

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Datasets Mentioned

BETA
GSE18716
CP001719

Methods Mentioned

BETA
electrophoresis
glycosylation
PCR
ELISA

Software Mentioned

PSORT
ROSO
Artemis
GenePix Pro
FGD
BLAST
ClustalW
Phred
NRPSpredictor
Staden package

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