The genomic features of parasitism, Polyembryony and immune evasion in the endoparasitic wasp Macrocentrus cingulum

BMC Genomics
Chuanlin YinXuexin Chen

Abstract

Parasitoid wasps are well-known natural enemies of major agricultural pests and arthropod borne diseases. The parasitoid wasp Macrocentrus cingulum (Hymenoptera: Braconidae) has been widely used to control the notorious insect pests Ostrinia furnacalis (Asian Corn Borer) and O. nubilalis (European corn borer). One striking phenomenon exhibited by M. cingulum is polyembryony, the formation of multiple genetically identical offspring from a single zygote. Moreover, M. cingulum employs a passive parasitic strategy by preventing the host's immune system from recognizing the embryo as a foreign body. Thus, the embryos evade the host's immune system and are not encapsulated by host hemocytes. Unfortunately, the mechanism of both polyembryony and immune evasion remains largely unknown. We report the genome of the parasitoid wasp M. cingulum. Comparative genomics analysis of M. cingulum and other 11 insects were conducted, finding some gene families with apparent expansion or contraction which might be linked to the parasitic behaviors or polyembryony of M. cingulum. Moreover, we present the evidence that the microRNA miR-14b regulates the polyembryonic development of M. cingulum by targeting the c-Myc Promoter-binding Protein 1 (MBP-1...Continue Reading

References

May 31, 1996·The Journal of Biological Chemistry·U TheopoldD Hultmark
Jan 1, 1997·Current Topics in Developmental Biology·M R Strand, M Grbic
Dec 24, 1998·Nucleic Acids Research·G Benson
Jan 27, 1999·Bioinformatics·D Posada, K A Crandall
May 11, 2002·Briefings in Bioinformatics·Sue A Olson
Jul 26, 2002·Briefings in Bioinformatics·Vladimir Makarov
Aug 15, 2002·Genome Research·Zhirong Bao, Sean R Eddy
May 29, 2003·Journal of Insect Physiology·W KinuthiaU Theopold
Sep 4, 2003·Genome Research·Li LiDavid S Roos
Mar 12, 2004·Annual Review of Entomology·D K Yeates, B M Wiegmann
May 18, 2004·BMC Bioinformatics·Ian Korf
Jun 25, 2004·Nucleic Acids Research·Mario StankeBurkhard Morgenstern
Sep 24, 2004·RNA·Marc RehmsmeierRobert Giegerich
Oct 27, 2004·PLoS Biology·Bino JohnDebora S Marks
Nov 13, 2004·Trends in Microbiology·Richard V GlatzOtto Schmidt
Apr 5, 2005·The Journal of Biological Chemistry·Asish K GhoshRatna B Ray
Jun 18, 2005·Bioinformatics·Alkes L PricePavel A Pevzner
Dec 8, 2005·Annual Review of Entomology·Francesco Pennacchio, Michael R Strand
Dec 31, 2005·Nucleic Acids Research·Heng LiRichard Durbin
Mar 18, 2006·Bioinformatics·Tijl De BieMatthew W Hahn
Sep 26, 2007·Nature Genetics·Michael KerteszEran Segal
Mar 3, 2009·Genome Research·Jared T SimpsonInanç Birol
Mar 6, 2009·Genome Biology·Ben LangmeadSteven L Salzberg
Mar 18, 2009·Bioinformatics·Cole TrapnellSteven L Salzberg
Mar 25, 2009·Bioinformatics·Eric P NawrockiSean R Eddy
Dec 17, 2009·Nature·Ruiqiang LiJun Wang
Feb 12, 2010·Cold Spring Harbor Protocols·John H Werren, David W Loehlin
Mar 18, 2010·BMC Bioinformatics·José Afonso Guerra-Assunção, Anton J Enright
May 22, 2010·Cell Biology International·Regalla Kumarswamy, Sudhir Chandna
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ewen F KirknessBarry R Pittendrigh
Jul 16, 2010·Journal of Evolutionary Biology·M SegoliT Keasar
Aug 11, 2010·Trends in Molecular Medicine·Monique T BarakatMatthew P Scott
Dec 15, 2010·Bioinformatics·Marten BoetzerWalter Pirovano
Dec 17, 2010·Genes & Development·Jishy VargheseStephen M Cohen
Jan 11, 2011·Bioinformatics·Guillaume Marçais, Carl Kingsford
Feb 18, 2011·Molecular Biology of the Cell·Pegine B WalradJ Peter Gergen
May 17, 2011·Nature Biotechnology·Manfred G GrabherrAviv Regev
Sep 9, 2011·Current Protocols in Bioinformatics·Steve FischerChristian J Stoeckert
Nov 9, 2011·Methods in Molecular Biology·Emily E Hare, J Spencer Johnston
Mar 1, 2012·Methods in Molecular Biology·Sébastien Tempel

❮ Previous
Next ❯

Citations

Jun 21, 2020·Molecular Ecology Resources·Xinhai YeGongyin Ye
Apr 11, 2019·Frontiers in Physiology·Qiang ZhangJin-Jun Wang
Jun 27, 2020·Insects·Maurizio Francesco Brivio, Maristella Mastore
Jan 16, 2021·Biology·Donald L J Quicke, Buntika A Butcher
May 15, 2021·Genome Biology and Evolution·Gaelen R BurkeBarbara J Sharanowski

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation
flow cytometry
RNA-Seq
PCR
electrophoresis
PCRs
transfection
Assay

Software Mentioned

NetOGlyc
NetPHos
TargetScan
SNAP
house
Trinity
RepeatScount
SOAP
MUSCLE
RECON

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.