The genomic landscape of Neanderthal ancestry in present-day humans

Nature
Sriram SankararamanDavid Reich

Abstract

Genomic studies have shown that Neanderthals interbred with modern humans, and that non-Africans today are the products of this mixture. The antiquity of Neanderthal gene flow into modern humans means that genomic regions that derive from Neanderthals in any one human today are usually less than a hundred kilobases in size. However, Neanderthal haplotypes are also distinctive enough that several studies have been able to detect Neanderthal ancestry at specific loci. We systematically infer Neanderthal haplotypes in the genomes of 1,004 present-day humans. Regions that harbour a high frequency of Neanderthal alleles are enriched for genes affecting keratin filaments, suggesting that Neanderthal alleles may have helped modern humans to adapt to non-African environments. We identify multiple Neanderthal-derived alleles that confer risk for disease, suggesting that Neanderthal alleles continue to shape human biology. An unexpected finding is that regions with reduced Neanderthal ancestry are enriched in genes, implying selection to remove genetic material derived from Neanderthals. Genes that are more highly expressed in testes than in any other tissue are especially reduced in Neanderthal ancestry, and there is an approximately fi...Continue Reading

References

Sep 19, 2000·Nature·J M Diamond
Jul 28, 2001·Evolution; International Journal of Organic Evolution·H A Orr, M Turelli
Dec 8, 2006·Bioinformatics·Garrett Hellenthal, Matthew Stephens
Mar 9, 2007·Bioinformatics·Tancred Frickey, Georg Weiller
Jun 3, 2008·Trends in Genetics : TIG·Daven C Presgraves
May 9, 2009·PLoS Genetics·Graham McVickerPhil Green
May 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lucia A HindorffTeri A Manolio
May 8, 2010·Science·Richard E GreenSvante Pääbo
Oct 29, 2010·Genome Biology·Simon Anders, Wolfgang Huber
Nov 16, 2010·Genome Génome / Conseil National De Recherches Canada·Bruce S Weir
Jan 27, 2011·Molecular Biology and Evolution·Vania YotovaDamian Labuda
Apr 12, 2012·Genetics·Simon Gravel
Aug 14, 2012·American Journal of Human Genetics·Fernando L MendezMichael F Hammer
Sep 1, 2012·Science·Matthias MeyerSvante Pääbo
Sep 7, 2012·Genome Génome / Conseil National De Recherches Canada·Jianshu ChenYudong Li
Oct 12, 2012·PLoS Genetics·Sriram SankararamanDavid Reich
Nov 7, 2012·Nature·Goncalo R AbecasisGil A McVean
Jan 15, 2013·Molecular Biology and Evolution·Fernando L MendezMichael F Hammer
Feb 16, 2013·Genetics·Jeffrey D WallMontgomery Slatkin
Dec 20, 2013·Nature·Kay PrüferSvante Pääbo
Aug 1, 1992·Evolution; International Journal of Organic Evolution·Priscilla K TuckerEva M Eicher

Citations

Jun 27, 2014·PLoS Genetics·Yaniv BrandvainAndrea L Sweigart
Apr 9, 2014·Nature Reviews. Genetics·Jeffrey Rogers, Richard A Gibbs
May 17, 2014·Molecular Biology and Evolution·Krishna R VeeramahMichael F Hammer
Dec 10, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Federico Sánchez-Quinto, C Lalueza-Fox
Aug 31, 2014·Molecular Biology and Evolution·Fernando RacimoMontgomery Slatkin
Sep 25, 2014·Annual Review of Genetics·Thomas MailundMikkel Heide Schierup
Sep 6, 2014·Current Opinion in Immunology·Laure Ségurel, Lluis Quintana-Murci
Aug 26, 2014·The Journal of Heredity·Richard G Harrison, Erica L Larson
Feb 18, 2016·Immunity·Mihai G Netea, Leo A B Joosten
Feb 26, 2016·Science·Corinne N SimontiJohn A Capra
Feb 28, 2016·Genome Biology·Wei ZhangMarcus R Kronforst
Jul 29, 2015·Current Opinion in Rheumatology·Timothy B Niewold
Dec 15, 2015·The American Naturalist·Matthew D McGeePeter C Wainwright
Feb 6, 2016·American Journal of Human Genetics·Jing ZhaoGreg Gibson
Feb 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·William GilpinKenichi Aoki
Jan 11, 2016·American Journal of Human Genetics·Matthieu DeschampsLluis Quintana-Murci
Jan 13, 2016·Genome Biology·Marc HaberChris Tyler-Smith
Dec 25, 2015·Proceedings. Biological Sciences·Mirte BosseMartien A M Groenen
Oct 10, 2015·Cell·Selina Vattathil, Joshua M Akey
Sep 5, 2015·Current Opinion in Genetics & Development·Corinne N Simonti, John A Capra
Dec 3, 2014·Trends in Genetics : TIG·William Klitz
Nov 29, 2015·Genome Biology and Evolution·Jacob E CrawfordBrian P Lazzaro
Sep 30, 2015·Pathologie-biologie·J Labat-Robert, L Robert
Jun 24, 2014·Journal of Molecular Evolution·John S Taylor
Jul 15, 2015·Journal of Human Evolution·Hugo Reyes-CentenoKaterina Harvati
Aug 15, 2014·Evolutionary Anthropology·Kenneth M Weiss, Holly Dunsworth
Mar 19, 2016·Nature Communications·Felix M KeyAida M Andrés
Nov 22, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·P J Steer
Feb 26, 2016·Genome Biology and Evolution·Larisa FedorovaAlexei Fedorov
Aug 27, 2015·Wiley Interdisciplinary Reviews. Cognitive Science·Sverker Johansson
Apr 2, 2016·Current Biology : CB·Sriram SankararamanDavid Reich
Apr 8, 2014·Trends in Ecology & Evolution·Chris Stringer
Jun 25, 2015·Molecular Biology and Evolution·Pengfei Qin, Mark Stoneking
Apr 9, 2016·American Journal of Human Genetics·Fernando L MendezCarlos D Bustamante
Sep 24, 2014·Current Biology : CB·Benjamin Vernot, Joshua M Akey
Apr 12, 2016·American Journal of Physical Anthropology·Charlotte J Houldcroft, Simon J Underdown
Jun 30, 2015·Evolution; International Journal of Organic Evolution·Jeffrey M GoodKe Bi
Sep 23, 2014·American Journal of Physical Anthropology·Stéphane BoissinotMarc Tollis
Nov 13, 2014·American Journal of Physical Anthropology·Maureen J Devlin
Feb 17, 2015·American Journal of Human Genetics·Benjamin Vernot, Joshua M Akey
Dec 3, 2014·Current Opinion in Genetics & Development·Michael C CampbellSarah Tishkoff
Oct 7, 2014·Current Opinion in Genetics & Development·Janet Kelso, Kay Prüfer
May 2, 2015·Journal of Human Evolution·Yolanda Fernández-JalvoHaoWen Tong
May 8, 2015·Nature Reviews. Genetics·Matthew W SnyderJay Shendure
May 13, 2015·Nature Reviews. Genetics·Fernando RacimoEmilia Huerta-Sánchez
Apr 1, 2014·Cell·Svante Pääbo
Mar 5, 2016·Molecular Ecology·Molly SchumerPeter Andolfatto
Dec 3, 2014·Current Opinion in Immunology·Jessica F Brinkworth, Luis B Barreiro
Aug 27, 2014·Current Opinion in Genetics & Development·Vitor SousaLaurent Excoffier
Feb 2, 2015·Current Opinion in Cell Biology·Roy A QuinlanEhmke Pohl
Jan 4, 2015·Molecular Biology and Evolution·Yen-Lung LinOmer Gokcumen
Jan 27, 2015·Journal of Human Evolution·George H Perry, Ludovic Orlando
Dec 24, 2014·Journal of Human Evolution·Luca ErminiLudovic Orlando
Jan 8, 2015·Journal of Human Evolution·George H PerryAaron J Sams
Feb 11, 2015·Global Heart·Albert ZinkJohannes Krause
May 20, 2014·American Journal of Human Genetics·Leonardo ArbizaAlon Keinan
Nov 8, 2014·Science·Andaine Seguin-OrlandoEske Willerslev
Sep 24, 2014·Molecular Biology and Evolution·Simon H MartinChris D Jiggins
May 3, 2016·Nature·Qiaomei FuDavid Reich
Apr 24, 2016·Journal of Theoretical Biology·Lei ZhaoDavid Waxman
May 4, 2016·Proceedings of the National Academy of Sciences of the United States of America·Priya MoorjaniDavid Reich
Apr 24, 2016·Molecular Ecology·Bridgett M vonHoldtRobert K Wayne
Apr 8, 2015·PLoS Genetics·Jonathan TerhorstYun S Song
May 29, 2016·The Journal of Heredity·Lynda F Delph, Jeffery P Demuth
Jun 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·Montgomery Slatkin, Fernando Racimo
Jun 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·Wil Roebroeks, Marie Soressi
Jan 31, 2016·Molecular Ecology·Nathan K SchaeferRichard E Green
Feb 3, 2016·Molecular Ecology·Bret A Payseur, Loren H Rieseberg
Jun 15, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Marta Mirazón Lahr
Jun 19, 2016·Bioinformatics·Russell Corbett-Detig, Matt Jones
Jul 20, 2016·Journal of Biological Research·Kwang Hyun Ko
Jul 21, 2016·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Irina MorozovaTatiana V Tatarinova
Aug 30, 2016·American Journal of Human Genetics·Dongsheng LuShuhua Xu
Sep 7, 2016·Current Opinion in Genetics & Development·Timothy H Webster, Melissa A Wilson Sayres
Sep 9, 2016·Current Opinion in Genetics & Development·Montgomery Slatkin
Sep 20, 2016·Current Opinion in Genetics & Development·Nicole Creanza, Marcus W Feldman
Sep 24, 2016·Current Opinion in Genetics & Development·Jeffrey D Wall, Debora Yoshihara Caldeira Brandt
Oct 7, 2016·Current Opinion in Genetics & Development·Feng Gao, Alon Keinan
Oct 16, 2016·Current Opinion in Genetics & Development·Lauren Alpert Sugden, Sohini Ramachandran
Oct 17, 2016·Current Opinion in Genetics & Development·Yuval B Simons, Guy Sella
Sep 24, 2016·Molecular Ecology·C J AndersonTom K Walsh
Oct 30, 2016·Science·Marc de ManuelTomas Marques-Bonet
Nov 9, 2016·Genome Biology·Lluis Quintana-Murci
Oct 21, 2016·Molecular Biology and Evolution·Fernando RacimoEmilia Huerta-Sánchez
Dec 21, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Bastien LlamasLudovic Orlando
Jan 4, 2017·Médecine sciences : M/S·Matthieu Deschamps, Lluis Quintana-Murci
Nov 9, 2016·PLoS Genetics·Ivan JuricGraham Coop
Dec 10, 2016·Journal of Evolutionary Biology·J P BernardesD Greig
Nov 5, 2016·Annual Review of Animal Biosciences·David E MacHughLudovic Orlando
Feb 13, 2016·Scientific Reports·Christophe DufresnesMatthias Stöck
Sep 22, 2015·Scientific Reports·Guadalupe MongeGeraldine Finlayson
Mar 24, 2017·Molecular Biology and Evolution·Matthew T BuckleyRasmus Nielsen
Mar 30, 2017·The Journal of Experimental Medicine·Hélène Quach, Lluis Quintana-Murci
Apr 6, 2017·Molecular Ecology·Ronald M NelsonMatthew T Webster
Apr 27, 2017·Molecular Biology and Evolution·B JégouF Chalmel
Feb 10, 2017·Nature Communications·Cheng-Ruei LeeMagnus Nordborg
Jan 20, 2017·Nature·Rasmus NielsenEske Willerslev
Apr 6, 2017·BMC Bioinformatics·Nathan K SchaeferRichard E Green
Jun 25, 2017·Trends in Ecology & Evolution·Michael L Arnold, Krushnamegh Kunte
Jul 26, 2017·Proceedings of the National Academy of Sciences of the United States of America·Francesco d'ErricoMaría Fernanda Sánchez Goñi
Sep 12, 2017·International Journal of Molecular Sciences·Mengting HuangZuhong Lu
Mar 27, 2018·American Journal of Physical Anthropology·Kenneth M Weiss
Apr 11, 2018·Genome Biology and Evolution·Jessica NyeJaume Bertranpetit
Apr 1, 2018·Molecular Ecology·Matthias SteinrückenYun S Song
Jan 18, 2018·Nature Genetics·Anuradha JagadeesanAgnar Helgason
Oct 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Molly SchumerGil G Rosenthal
Aug 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Alan R RogersChad D Huff
Nov 3, 2017·Journal of Experimental Botany·Roswitha SchmicklLevi Yant
Jun 10, 2016·Bioinformatics and Biology Insights·Fredj Tekaia
Jan 1, 2015·Evolutionary Bioinformatics Online·Saioa LópezGarrett Hellenthal
Feb 18, 2016·Nature·Martin KuhlwilmSergi Castellano
Jun 1, 2018·PLoS Genetics·Aaron B Wolf, Joshua M Akey
Aug 8, 2018·Proceedings of the National Academy of Sciences of the United States of America·James F O'ConnellAlan Cooper
Aug 23, 2018·Evolutionary Anthropology·Julia M Zichello
May 2, 2018·Annual Review of Genomics and Human Genetics·Pontus Skoglund, Iain Mathieson
Sep 2, 2017·BMC Biology·Kelley Harris, Rasmus Nielsen
Sep 7, 2018·American Journal of Physical Anthropology·Michela LeonardiGuido Barbujani
Jan 22, 2015·Infection and Immunity·Ferric C Fang, Arturo Casadevall
Oct 23, 2018·PLoS Genetics·Bernard KimKirk E Lohmueller
Dec 6, 2018·Molecular Biology and Evolution·Lex FlagelDaniel R Schrider
Jan 18, 2018·Nature Ecology & Evolution·Anna RunemarkGlenn-Peter Sætre
Oct 2, 2018·Molecular Biology and Evolution·Groves DixonMark Kirkpatrick
Dec 20, 2018·Genome Biology and Evolution·David ReherJanet Kelso
Apr 27, 2019·American Journal of Physical Anthropology·Abel Marinus Bosman, Katerina Harvati
May 1, 2019·Nature Ecology & Evolution·Martin KuhlwilmTomas Marques-Bonet
Apr 4, 2019·Genome Biology and Evolution·Daniel N HarrisTimothy D O'Connor
Mar 29, 2014·Nature·Ewen Callaway
Jul 22, 2014·Nature·Emilia Huerta-SánchezRasmus Nielsen
Jan 18, 2019·Molecular Ecology·Krystyna Nadachowska-BrzyskaHans Ellegren
Sep 12, 2017·Nature Reviews. Genetics·Stephanie Marciniak, George H Perry
May 30, 2019·PloS One·Anna DegioanniSilvana Condemi
Jun 13, 2019·Proceedings. Biological Sciences·Daniel R ShultzThomas R Shultz
Jun 22, 2019·Molecular Biology and Evolution·Sergio TussoJ B W Wolf
Jun 22, 2019·Evolutionary Anthropology·Rebecca R AckermannDietmar Zinner
Jun 6, 2019·Annals of Human Biology·Cindy SantanderCristian Capelli
Sep 1, 2018·Molecular Biology and Evolution·Charleston W K ChiangSriram Sankararaman
Jun 21, 2014·Science·Jean-Jacques Hublin
Nov 16, 2014·Nucleic Acids Research·Scott Federhen
Aug 24, 2019·Current Osteoporosis Reports·Pushpanathan Muthuirulan, Terence D Capellini
Feb 24, 2017·Physiology·Stephen D R Harridge, Norman R Lazarus
Sep 1, 2017·Genome Biology and Evolution·Timothy A JinamNaruya Saitou
Aug 5, 2017·Molecular Ecology·Juan Enciso-RomeroCamilo Salazar
Aug 6, 2017·BMC Evolutionary Biology·Manjusha ChintalapatiKay Prüfer
Aug 10, 2017·Scientific Reports·Mario BarbatoMichael W Bruford
Feb 1, 2018·Annals of Human Biology·Maarten H D Larmuseau, Claudio Ottoni
Jul 7, 2019·Reviews in Endocrine & Metabolic Disorders·Malgorzata Monika BrzozowskaMurray P Cox
Nov 28, 2019·PLoS Genetics·Anna RunemarkJoana I Meier
Oct 7, 2017·Science·Kay PrüferSvante Pääbo
Jan 15, 2020·Molecular Biology and Evolution·Alexandre Gouy, Laurent Excoffier
May 23, 2019·FEBS Letters·Michał SzpakChris Tyler-Smith
Mar 10, 2020·PLoS Genetics·Ke WangStephan Schiffels
Nov 9, 2019·American Journal of Physical Anthropology·Omer Gokcumen
Sep 17, 2019·PLoS Genetics·Caiti S Smukowski HeilMaitreya J Dunham
Sep 14, 2017·PloS One·Clément ZanolliCatherine Mollereau
Sep 6, 2017·PLoS Genetics·David A Turissini, Daniel R Matute
Apr 24, 2020·Molecular Ecology Resources·Molly SchumerRuss Corbett-Detig
Jun 13, 2019·Scientific Reports·Martin Kuhlwilm, Cedric Boeckx
Jul 1, 2020·Laterality·Michael C Corballis
Apr 2, 2015·Molecular Endocrinology·Peter S Rotwein
Jul 30, 2020·The Journal of Heredity·Marcella D BaizLiliana Cortés-Ortiz
May 22, 2020·Molecular Biology and Evolution·Hugo ZebergSvante Pääbo
Aug 28, 2020·PLoS Genetics·Mehreen R MughalMichael DeGiorgio
Sep 27, 2019·Scientific Reports·Rodrigo SecolinDavid Comas
Jul 29, 2020·Nature Ecology & Evolution·David C RinkerJohn A Capra
Aug 22, 2015·Journal of Applied Physiology·Emilia Huerta-Sánchez, Fergal P Casey
Nov 10, 2015·Investigative Genetics·Francesca TassiGuido Barbujani
Dec 28, 2016·Molecular Biology and Evolution·Ville N PimenoffIgnacio G Bravo
Mar 4, 2017·Journal of Molecular Neuroscience : MN·Nguyen Thi Thanh HoKlaus Heese
Sep 1, 2017·Genome Biology and Evolution·Joel SharbroughDaniel B Sloan
May 12, 2018·BMC Evolutionary Biology·Niladri BanerjeeStephanie Le Hellard
Dec 6, 2018·Nature Reviews. Genetics·Michel GeorgesBen Hayes
Feb 18, 2019·Journal of Internal Medicine·W P T JamesP J Stover
Jan 17, 2019·Proceedings of the National Academy of Sciences of the United States of America·Martin PetrBenjamin Vernot
Feb 19, 2019·Frontiers in Plant Science·Concetta BurgarellaCécile Berthouly-Salazar
Mar 5, 2019·Evolutionary Applications·Chunyuan ZhangNing Li
Apr 15, 2020·Human Genetics·Luis B Barreiro, Lluis Quintana-Murci
Feb 6, 2017·Genome Biology and Evolution·Gundula Povysil, Sepp Hochreiter
Jul 14, 2017·Hereditas·Lian Deng, Shuhua Xu
Jul 12, 2017·G3 : Genes - Genomes - Genetics·Viranga Tilakaratna, Douda Bensasson
Jul 20, 2017·Genome Research·Stéphane PeyrégneKay Prüfer
Nov 21, 2017·Evolutionary Applications·Riaan F RifkinDon A Cowan
Apr 4, 2018·Proceedings of the National Academy of Sciences of the United States of America·Craig J AndersonTom K Walsh
Sep 13, 2018·Genetics·Paloma MedinaRussell Corbett-Detig
Aug 20, 2019·Molecular Biology and Evolution·Stéphane Aris-Brosou
Mar 21, 2019·Scientific Reports·Roberto SiricaVincenza Colonna
Apr 29, 2019·Human Genetics·Daniel John LawsonNicholas John Timpson
Dec 5, 2019·American Journal of Physical Anthropology·Miranda E Karban
Mar 21, 2020·Science·Anders BergströmChris Tyler-Smith
Jan 4, 2020·Genome Biology·Maxime Rotival, Lluis Quintana-Murci
May 3, 2020·Nature Communications·Samridhi ChaturvediZachariah Gompert
Jun 20, 2020·PLoS Genetics·Derek SetterJoachim Hermisson
Jun 18, 2020·Proceedings of the National Academy of Sciences of the United States of America·Fabrizio MafessoniSvante Pääbo
Aug 26, 2020·Nature Ecology & Evolution·Natalie TelisKelley Harris
Apr 3, 2016·Genetics·Kelley Harris, Rasmus Nielsen
Aug 1, 2015·Nature·Ewen Callaway
Oct 19, 2017·Genome Biology and Evolution·Recep Ozgur TaskentOmer Gokcumen
Jan 18, 2017·PLoS Genetics·Cathal Seoighe, Aylwyn Scally
Aug 23, 2017·Pharmaceutical Medicine·Nailú Angélica SinicatoTimothy B Niewold
Apr 4, 2017·Genome Biology·Michael DannemannJanet Kelso
Jul 26, 2017·Scientific Reports·Michael D GregoryKaren F Berman
Mar 20, 2019·American Journal of Physical Anthropology·Deven N Vyas, Connie J Mulligan
Dec 14, 2018·ELife·Colin D MeiklejohnDaven C Presgraves
Nov 16, 2018·Genes·Ben Jacob Novak
Mar 19, 2019·International Journal of Primatology·Liliana Cortés-OrtizDomingo Canales-Espinosa
Nov 26, 2019·American Journal of Physical Anthropology·Suzanna WhiteSimon Hillson
Feb 6, 2017·G3 : Genes - Genomes - Genetics·Evan Koch, John Novembre
Jan 31, 2019·Nature Ecology & Evolution·Scott A Taylor, Erica L Larson
Jul 31, 2018·Genome Biology·Fernando A SeixasJosé Melo-Ferreira
Nov 28, 2018·Nature Ecology & Evolution·Fernando A Villanea, Joshua G Schraiber
Nov 3, 2018·PeerJ·Farida S AkhtariAlison A Motsinger-Reif
Jan 6, 2018·Heredity·Molly SchumerPeter Andolfatto
Apr 3, 2018·Genome Biology and Evolution·Bárbara D BitarelloAida M Andrés
May 29, 2019·PLoS Genetics·Arun Durvasula, Sriram Sankararaman
May 16, 2020·Politics and the Life Sciences : the Journal of the Association for Politics and the Life Sciences·Samantha L Mosier
Oct 6, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David Enard, Dmitri A Petrov
Nov 30, 2018·Cancer Research·Melissa A BuckleyOvarian Cancer Association Consortium
Jan 7, 2021·Systematic Biology·Sungsik Kong, Laura S Kubatko

Related Concepts

Alleles
Metazoa
Hybridization, Intraspecies
Subfertility, Male
Keratin
Tissue Specificity
Phylogeny
Selection, Genetic
Testis
X Chromosome

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.